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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-12-17
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pubmed:abstractText |
Using clonogenic survival assays, we demonstrated that a new platinum-acridine hybrid agent, PT-ACRAMTU, is cytotoxic in SNB19 and U87MG glioblastoma cells at low-micromolar concentrations. PT-ACRAMTU is more cytotoxic than ACRAMTU (the platinum-free acridine), acts in a time and dose dependent manner, and appears to generate an apoptotic response in both cell lines on the basis of increased caspase-3 activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
443-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15603970-Acridines,
pubmed-meshheading:15603970-Animals,
pubmed-meshheading:15603970-Carmustine,
pubmed-meshheading:15603970-Caspase 3,
pubmed-meshheading:15603970-Caspases,
pubmed-meshheading:15603970-Cell Line,
pubmed-meshheading:15603970-Cisplatin,
pubmed-meshheading:15603970-Cross-Linking Reagents,
pubmed-meshheading:15603970-Dose-Response Relationship, Drug,
pubmed-meshheading:15603970-Drug Screening Assays, Antitumor,
pubmed-meshheading:15603970-Glioblastoma,
pubmed-meshheading:15603970-Inhibitory Concentration 50,
pubmed-meshheading:15603970-Organoplatinum Compounds,
pubmed-meshheading:15603970-Platinum
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pubmed:year |
2005
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pubmed:articleTitle |
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.
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pubmed:affiliation |
Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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