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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2004-12-17
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pubmed:abstractText |
An injectable delivery system for prednisolone has been prepared based on a self-curing formulation comprised of poly(methyl methacrylate) particles and hydroxyethyl methacrylate as monomer. The polymerisation reaction was initiated by the redox system 4,4'-bis (dimethylaminobenzydrol)/benzoyl peroxide (BZN/BPO) and followed at 25 degrees C by measuring the time-temperature profile. A maximum temperature of 53 degrees C and a setting time of 15 min were obtained, calculated according to standard specifications. The swelling of the cured system was studied in phosphate-buffered saline (PBS) at 37 degrees C giving a hydration degree at equilibrium of 20%. The swelling kinetics fitted a fickian behaviour at the initial stages of the experiments, with a diffusion coefficient of 0.72 x 10(-7) cm2/s. The release of the drug was sustained from the beginning without an initial drug burst. The study of the wettability showed a rather hydrophilic character of the surface of the loaded system, and the biocompatibility evaluated through MTT assay revealed the absence of cytotoxicity due to the release of toxic substances.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoyl Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Methylmethacrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Polymethyl Methacrylate,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/Steroids,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0142-9612
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3311-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15603826-Animals,
pubmed-meshheading:15603826-Benzoyl Peroxide,
pubmed-meshheading:15603826-Biocompatible Materials,
pubmed-meshheading:15603826-Coloring Agents,
pubmed-meshheading:15603826-Diffusion,
pubmed-meshheading:15603826-Drug Carriers,
pubmed-meshheading:15603826-Drug Delivery Systems,
pubmed-meshheading:15603826-Ear Diseases,
pubmed-meshheading:15603826-Glucocorticoids,
pubmed-meshheading:15603826-Humans,
pubmed-meshheading:15603826-Kinetics,
pubmed-meshheading:15603826-Methylmethacrylates,
pubmed-meshheading:15603826-Microscopy, Electron,
pubmed-meshheading:15603826-Models, Chemical,
pubmed-meshheading:15603826-Oxidation-Reduction,
pubmed-meshheading:15603826-Polymers,
pubmed-meshheading:15603826-Polymethyl Methacrylate,
pubmed-meshheading:15603826-Prednisolone,
pubmed-meshheading:15603826-Steroids,
pubmed-meshheading:15603826-Temperature,
pubmed-meshheading:15603826-Tetrazolium Salts,
pubmed-meshheading:15603826-Thiazoles,
pubmed-meshheading:15603826-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Self-curing controlled release systems for steroids. Application of prednisolone-based polymeric systems to ear diseases.
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pubmed:affiliation |
Instituto de Ciencia y Tecnología de Polímeros, CSIC, C/Juan de la Cierva, 3, 28006 Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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