Linked Life Data

1560254

Source:http://linkedlifedata.com/resource/pubmed/id/1560254

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-5-14
pubmed:abstractText
Microtubule-associated proteins appear to be critical elements in the stabilization of microtubules during neurite development. Axon injury results in a new burst of axonal growth activity as well as in partial dendritic involution. With this background we have examined the immunocytochemical staining pattern for microtubule-associated proteins 2, 3 and 5 in the hypoglossal nucleus of adult rats following unilateral hypoglossal nerve resection. From four days to six weeks postlesion a significant reduction in microtubule-associated protein 2-like immunoreactivity was observed in the neuropil and neuronal perikarya of the hypoglossal nucleus ipsilateral to nerve transaction. Microtubule-associated protein 5-like immunoreactivity was reduced in neuronal perikarya and neuropil four days to two weeks after injury. After six weeks microtubule-associated protein 5-like immunoreactivity had returned to normal levels. Microtubule-associated protein 3-like immunoreactivity, which was observed in glial cell perikarya and axons, but not neuronal perikarya or dendrites, appeared to be essentially unaltered. The reduced levels of microtubule-associated proteins 2 and 5 may be factors contributing to previously documented axotomy-induced dendritic retraction. The decrease in microtubule-associated protein 5 staining and absence of microtubule-associated protein 3 expression in axotomized neurons contrast with the situation in developing neurons, and demonstrate that the neuronal reaction to axon injury in mature mammals involves a specific series of events distinct from the developmental process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-4864
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
The effect of axon injury on microtubule-associated proteins MAP2, 3 and 5 in the hypoglossal nucleus of the adult rat.
pubmed:affiliation
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't