| pubmed-article:1560200 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1560200 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1560200 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:1560200 | lifeskim:mentions | umls-concept:C0017953 | lld:lifeskim |
| pubmed-article:1560200 | lifeskim:mentions | umls-concept:C0678836 | lld:lifeskim |
| pubmed-article:1560200 | lifeskim:mentions | umls-concept:C1518124 | lld:lifeskim |
| pubmed-article:1560200 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1560200 | pubmed:dateCreated | 1992-5-13 | lld:pubmed |
| pubmed-article:1560200 | pubmed:abstractText | The T cell independence of complex polysaccharide Ag has suggested the possibility that carbohydrates may be incapable of T cell recognition because of a failure to interact with MHC restriction elements and/or a failure of MHC/carbohydrate complexes to interact with and be recognized by Ag-specific TCR. We have used two approaches to obtain information about T cell recognition of carbohydrate. First, we have determined the capacity of a series of oligosaccharides and glycolipids to bind a murine class II MHC molecule, IAd. No significant binding was observed with the 26 compounds tested, but the limitation to these studies was that there was a relatively limited collection of synthetic carbohydrate and glycolipid structures of limited complexity available for analysis. The second approach involved the study of the effect of glycosylation of a known peptide T cell epitope (OVA 323-339) on MHC binding of the peptide and on T cell recognition. Three patterns of effects were observed: 1) no effect on either binding or T cell recognition. This pattern was observed when the carbohydrate was located at residues removed from the core MHC-binding region. When the carbohydrate was located within the core MHC-binding regions, either 2) glycosylation destroyed both MHC binding and T cell recognition; or 3) glycosylation did not ablate MHC binding or T cell recognition. In this latter instance, there was evidence to indicate that the carbohydrate moiety was an important part of the antigenic determinant recognized by T cells. | lld:pubmed |
| pubmed-article:1560200 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1560200 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1560200 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1560200 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1560200 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1560200 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1560200 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1560200 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1560200 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1560200 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:GreyH MHM | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:ThomsonDD | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:GaetaF CFC | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:SettiEE | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:LamontA GAG | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:IshiokaG YGY | lld:pubmed |
| pubmed-article:1560200 | pubmed:author | pubmed-author:BulbowNN | lld:pubmed |
| pubmed-article:1560200 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1560200 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1560200 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1560200 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1560200 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1560200 | pubmed:pagination | 2446-51 | lld:pubmed |
| pubmed-article:1560200 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1560200 | pubmed:meshHeading | pubmed-meshheading:1560200-... | lld:pubmed |
| pubmed-article:1560200 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1560200 | pubmed:articleTitle | MHC interaction and T cell recognition of carbohydrates and glycopeptides. | lld:pubmed |
| pubmed-article:1560200 | pubmed:affiliation | Cytel, San Diego, CA 92121. | lld:pubmed |
| pubmed-article:1560200 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1560200 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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