Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-16
pubmed:abstractText
OBJECTIVE: To produce high quality factor IX complex concentrates with domestic ion exchanger. A human solvent-detergent (S/D) treated factor IX complex concentrates has been produced from fresh-frozen plasma using domestic DEAE-Sepharose fast flow ion exchange chromatagraphy and Ca3(PO4)2 adsorption. The properties of this new concentrates were compared with those of the concentrates obtained by foreign DEAE-Sapharose CL-6B. RESULTS: The recovery of activity was 93.67 +/- 2.56% (n = 6) and 88.71 +/- 2 (n = 6), respectively. The specific activity of the concentrates was 7.36 +/- 0.96 U Factor IX: C/mg protein (n = 6). This new concentrates retained all the useful components with higher purity and lower thrombogenicity. Conclusion Domestic ion exchanger could replace foreign ion exchanger in producing high quality factor IX complex concentrates.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1672-173X
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Technology optimization and properties study of factor IV complex concentrates].
pubmed:affiliation
Department of Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
pubmed:publicationType
Journal Article, English Abstract