Source:http://linkedlifedata.com/resource/pubmed/id/15598567
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2004-12-15
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| pubmed:abstractText |
To obtain information of structure-activity relationships (SARs) of 13-deoxytedanolide, its chemical transformation has been carried out, targeting on such functional groups as an epoxide, hydroxyls, ketones, and olefins. A total of 10 derivatives have been prepared and their cytotoxicity against P388 murine leukemia cells and inhibitory activity of polypeptide elongation in yeast cell lysate provided some important SARs; the southern hemisphere comprises the pharmacophore, while the epoxide-bearing side chain is essential for the activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
455-62
|
| pubmed:meshHeading |
pubmed-meshheading:15598567-Animals,
pubmed-meshheading:15598567-Antineoplastic Agents,
pubmed-meshheading:15598567-Cell Line, Tumor,
pubmed-meshheading:15598567-Macrolides,
pubmed-meshheading:15598567-Models, Molecular,
pubmed-meshheading:15598567-Molecular Structure,
pubmed-meshheading:15598567-Porifera,
pubmed-meshheading:15598567-Protein Synthesis Inhibitors,
pubmed-meshheading:15598567-Saccharomyces cerevisiae,
pubmed-meshheading:15598567-Structure-Activity Relationship
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Structure-activity relationship study on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens.
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| pubmed:affiliation |
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
|
| pubmed:publicationType |
Journal Article
|