Linked Life Data

1559843

Source:http://linkedlifedata.com/resource/pubmed/id/1559843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-5-14
pubmed:abstractText
The lectins DBA, WGA, SBA, Con A, GS-1, LFA and PNA were used to characterize the carbohydrate domains of the rat neuromuscular junction. DBA stained only the synaptic domains of muscle surface. All other lectins stained the whole muscle surface but the intensity of staining was stronger at the synaptic regions. However, when sections were treated with several digestive agents prior to lectin application, the lectin staining pattern changed dramatically. Collagenase-sensitive GlcNac, Mannose, Sialic acid, and GalNac-containing glycoconjugates associated with synaptic regions but not present extrasynaptically were revealed after chemical treatment. On the basis of these modifications it is proposed that, apart from the synapse-specific GalNac-containing glycoconjugate already described elsewhere, new carbohydrate-containing compounds are evidenced. These results provide a new insight into regional specialization of the extracellular matrix associated with the neuromuscular junctions and indicates that pretreatment with various agents, not necessary digestive substances, may alter molecular properties of muscle membrane and uncover previously unknown binding sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5564
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-31
pubmed:dateRevised
2008-1-29
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Treatment with digestive agents reveals several glycoconjugates specifically associated with rat neuromuscular junction.
pubmed:affiliation
Universitat de Barcelona, Estudi General de Lleida, Facultat de Medicina, Departament de Ciències Mèdiques Bàsiques, Catalonia, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't