Linked Life Data

15596244

Source:http://linkedlifedata.com/resource/pubmed/id/15596244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-14
pubmed:abstractText
It has been reported in the cat and rat that inhibitory premotor neurons, which send their axons to motoneurons of the trigeminal motor nucleus (Vm) are distributed in the reticular regions around the Vm, especially in the supratrigeminal region (Vsup) and the intertrigeminal region (Vint). In the present study, we examined neuronal connections of GABAergic neurons in the Vsup and Vint in the mouse by utilizing the adult heterozygous GAD67-GFP knock-in mouse, in which green fluorescence protein (GFP) is expressed in GABAergic neurons under the control of the endogenous GAD (GAD67) gene promoter [Yanagawa, Y., Kaneko, K., Kanbara, N., Totsuka, M., Yagi, T., Obata, K., 2001. Development of mouse expressing GFP in GABAergic neurons. Neurosci. Res. Suppl. 25, S77; Tamamaki, N., Yanagawa, Y., Tomioka, R., Miyazaki, J.-I., Obata, K., Kaneko, T., 2003. Green fluorescent protein expression and colocalization with calretinin, parvalbumin and somatostatin in the GAD67-GFP knock-in mouse. J. Comp. Neurol. 467, 60-79]. The connections were examined light- and electron-microscopically by combining the anterograde or the retrograde tract-tracing method with the immunohistochemical method for GFP. The data indicated that the Vsup and Vint of the mouse contained GABAergic neurons, which received projection fibers from the marginal layer of the nucleus of the spinal tract of the trigeminal nerve (Vc) on the ipsilateral side and sent their axons to the Vm on the contralateral side. Some of these GABAergic neurons may represent Vm-premotor neurons that receive nociceptive input from the Vc to elicit jaw-opening reflex by inhibiting jaw-closing Vm-motoneurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-91
pubmed:dateRevised
2007-10-24
pubmed:meshHeading
pubmed-meshheading:15596244-Animals, pubmed-meshheading:15596244-Biotin, pubmed-meshheading:15596244-Dextrans, pubmed-meshheading:15596244-Glutamate Decarboxylase, pubmed-meshheading:15596244-Green Fluorescent Proteins, pubmed-meshheading:15596244-Immunohistochemistry, pubmed-meshheading:15596244-In Situ Hybridization, pubmed-meshheading:15596244-Isoenzymes, pubmed-meshheading:15596244-Mice, pubmed-meshheading:15596244-Mice, Transgenic, pubmed-meshheading:15596244-Microscopy, Immunoelectron, pubmed-meshheading:15596244-Neural Pathways, pubmed-meshheading:15596244-Neurons, pubmed-meshheading:15596244-RNA, Messenger, pubmed-meshheading:15596244-Trigeminal Nuclei, pubmed-meshheading:15596244-Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, pubmed-meshheading:15596244-gamma-Aminobutyric Acid
pubmed:year
2005
pubmed:articleTitle
Efferent and afferent connections of GABAergic neurons in the supratrigeminal and the intertrigeminal regions. An immunohistochemical tract-tracing study in the GAD67-GFP knock-in mouse.
pubmed:affiliation
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't