| pubmed-article:1559579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0024117 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0264492 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C1510824 | lld:lifeskim |
| pubmed-article:1559579 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:1559579 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1559579 | pubmed:dateCreated | 1992-5-13 | lld:pubmed |
| pubmed-article:1559579 | pubmed:abstractText | The calf muscle energy metabolism of 8 stable chronic obstructive pulmonary disease (COPD) patients with chronic respiratory failure (arterial oxygen tension (Pao2) 7.7 +/- 0.4 kPa or 58 +/- 3 mmHg) was studied, using 31-phosphorus magnetic resonance spectroscopy (31P MRS). MRS spectra were acquired at rest and during the course of 360 pedal movements at 20, 35 and 50% of the maximal voluntary contraction (MVC) and during recovery. Eight healthy age-matched subjects served as the control group. No significant differences between groups were observed in resting muscle, as regards intracellular pH, Pi/PCr ratio (Pi: inorganic phosphate; PCr: phosphocreatine) and the relative ATP expressed as the ratio beta ATP/PCr + Pi + PME (PME: phosphomonoester). Although effective power outputs were similar for both groups at each work level, COPD patients exhibited a higher Pi/PCr ratio than health controls (3.34 +/- 0.89 vs 0.49 +/- 0.05 at 50% MVC; p less than 0.01) and a lower pHi (6.65 +/- 0.11 vs 7.06 +/- 0.02 at 50% MVC; p less than 0.01). PCr resynthesis during recovery was slower in patients than in control subjects (t1/2 PCr 1.27 +/- 0.26 min vs 0.47 +/- 0.05 min; p less than 0.05). These results suggest impairment of aerobic capacity in a non-ventilatory working muscle, which may be due to hypoxaemia in patients with chronic respiratory failure. | lld:pubmed |
| pubmed-article:1559579 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1559579 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1559579 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1559579 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1559579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1559579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1559579 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1559579 | pubmed:issn | 0903-1936 | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:LevyPP | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:BenabidA LAL | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:Le BasJ FJF | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:WuyamBB | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:ReutenauerHH | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:PayenJ FJF | lld:pubmed |
| pubmed-article:1559579 | pubmed:author | pubmed-author:BensaïdaneHH | lld:pubmed |
| pubmed-article:1559579 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1559579 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1559579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1559579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1559579 | pubmed:pagination | 157-62 | lld:pubmed |
| pubmed-article:1559579 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
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| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
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| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
| pubmed-article:1559579 | pubmed:meshHeading | pubmed-meshheading:1559579-... | lld:pubmed |
| pubmed-article:1559579 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1559579 | pubmed:articleTitle | Metabolism and aerobic capacity of skeletal muscle in chronic respiratory failure related to chronic obstructive pulmonary disease. | lld:pubmed |
| pubmed-article:1559579 | pubmed:affiliation | Dept. of Respiratory Medicine, CHU Grenoble, France. | lld:pubmed |
| pubmed-article:1559579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1559579 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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