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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-5-13
|
| pubmed:abstractText |
The calf muscle energy metabolism of 8 stable chronic obstructive pulmonary disease (COPD) patients with chronic respiratory failure (arterial oxygen tension (Pao2) 7.7 +/- 0.4 kPa or 58 +/- 3 mmHg) was studied, using 31-phosphorus magnetic resonance spectroscopy (31P MRS). MRS spectra were acquired at rest and during the course of 360 pedal movements at 20, 35 and 50% of the maximal voluntary contraction (MVC) and during recovery. Eight healthy age-matched subjects served as the control group. No significant differences between groups were observed in resting muscle, as regards intracellular pH, Pi/PCr ratio (Pi: inorganic phosphate; PCr: phosphocreatine) and the relative ATP expressed as the ratio beta ATP/PCr + Pi + PME (PME: phosphomonoester). Although effective power outputs were similar for both groups at each work level, COPD patients exhibited a higher Pi/PCr ratio than health controls (3.34 +/- 0.89 vs 0.49 +/- 0.05 at 50% MVC; p less than 0.01) and a lower pHi (6.65 +/- 0.11 vs 7.06 +/- 0.02 at 50% MVC; p less than 0.01). PCr resynthesis during recovery was slower in patients than in control subjects (t1/2 PCr 1.27 +/- 0.26 min vs 0.47 +/- 0.05 min; p less than 0.05). These results suggest impairment of aerobic capacity in a non-ventilatory working muscle, which may be due to hypoxaemia in patients with chronic respiratory failure.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0903-1936
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
157-62
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1559579-Aged,
pubmed-meshheading:1559579-Anoxia,
pubmed-meshheading:1559579-Anthropometry,
pubmed-meshheading:1559579-Energy Metabolism,
pubmed-meshheading:1559579-Exercise,
pubmed-meshheading:1559579-Humans,
pubmed-meshheading:1559579-Lung Diseases, Obstructive,
pubmed-meshheading:1559579-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1559579-Middle Aged,
pubmed-meshheading:1559579-Muscle Contraction,
pubmed-meshheading:1559579-Muscles,
pubmed-meshheading:1559579-Phosphates,
pubmed-meshheading:1559579-Respiratory Function Tests,
pubmed-meshheading:1559579-Respiratory Insufficiency
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Metabolism and aerobic capacity of skeletal muscle in chronic respiratory failure related to chronic obstructive pulmonary disease.
|
| pubmed:affiliation |
Dept. of Respiratory Medicine, CHU Grenoble, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|