Linked Life Data

1559558

Source:http://linkedlifedata.com/resource/pubmed/id/1559558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-5-13
pubmed:databankReference
pubmed:abstractText
A cDNA clone corresponding to chicken aldehyde dehydrogenase (ALDH) mRNA was isolated from a library representing the polyadenylated RNAs expressed in the retina of day 3.5 chick embryos. The profile of ALDH RNA expression was examined in different tissues as well as at different stages of development in the chick embryo. A notable feature of this analysis was the high level of ALDH transcripts found in the undifferentiated cells of the retina. A 20-fold decrease in ALDH RNA levels was observed upon retinal differentiation, in contrast to the kidney, liver and gut where tissue maturation was accompanied by an increase in ALDH mRNA levels. The observations reported here suggest an important role for the ALDH enzyme in retinal development. One possibility is that retinal, the aldehyde form of vitamin A, serves as a substrate for ALDH in the developing retina, resulting in the formation of retinoic acid which has been implicated in various differentiation processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-305
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
High levels of aldehyde dehydrogenase transcripts in the undifferentiated chick retina.
pubmed:affiliation
Cross Cancer Institute, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't