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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-5-13
|
| pubmed:abstractText |
As part of research of juvenile hypertension the authors assessed the types of HLA antigens loci A and B in 242 children, adolescents and young adults with asymptomatic primary hypertension. The control group was formed by 300 normotonic blood donors. In the group of hypertonic subjects a significantly higher frequency of HLA-B5 antigen was found and a lower frequency of HLA-B8 and B35. Classification of the group of patients by the type of raised BP revealed the following: in subjects with a variable BP, as compared with the control group, antigens HLA-A1, B8, B35 and B40 were less frequent, in subjects with a permanently elevated blood pressure antigen HLA-B5 was more frequent and conversely antigen HLA-B35 was less frequent than in healthy subjects. From the investigation ensues a probable relationship between the presence of antigen HLA-B5 and the greater risk of the subsequent manifestation of the disease and conversely between the presence of antigen HLA-B35 in subjects at risk and probably a favourable prognosis of blood pressure readings. Contemporary findings cannot yet be considered unequivocal and it will be necessary to test their validity by extending the number of examined subjects.
|
| pubmed:language |
cze
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0069-2328
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
9-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1992
|
| pubmed:articleTitle |
[Relation between the HLA system and juvenile hypertension].
|
| pubmed:affiliation |
Klinika d?tí a dorostu, 3. LF UK, Praha.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|