15591839

Source:http://linkedlifedata.com/resource/pubmed/id/15591839

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014323, umls-concept:C0027950, umls-concept:C0086418, umls-concept:C0162638, umls-concept:C0302523, umls-concept:C0700325, umls-concept:C1444748
pubmed:issue	4
pubmed:dateCreated	2004-12-13
pubmed:abstractText	Neutrophils are important effector cells against protozoan extracellular parasite Entamoeba histolytica, which causes amoebic colitis and liver abscess in human beings. Apoptotic cell death of neutrophils is an important event in the resolution of inflammation and parasite's survival in vivo. This study was undertaken to investigate the ultrastructural aspects of apoptotic cells during neutrophil death triggered by Entamoeba histolytica. Isolated human neutrophils from the peripheral blood were incubated with or without live trophozoites of E. histolytica and examined by transmission electron microscopy (TEM). Neutrophils incubated with E. histolytica were observed to show apoptotic characteristics, such as compaction of the nuclear chromatin and swelling of the nuclear envelop. In contrast, neutrophils incubated in the absence of the amoeba had many protrusions of irregular cell surfaces and heterogenous nuclear chromatin. Therefore, it is suggested that Entamoeba-induced neutrophil apoptosis contribute to prevent unwanted tissue inflammation and damage in the amoeba-invaded lesions in vivo.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-11044212, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-11140454, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-11207613, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-12142490, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-12243737, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-12554533, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-12660071, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-12752675, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-7879672, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-7957763, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-8430086, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-9103222, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-9284127, http://linkedlifedata.com/resource/pubmed/commentcorrection/15591839-9284178
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9435800
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0023-4001
pubmed:author	pubmed-author:ImKyung-ilKI, pubmed-author:KimKyeong AhKA, pubmed-author:ParkSoon-JungSJ, pubmed-author:ShinMyeong HeonMH, pubmed-author:SimSeoboS, pubmed-author:YongTai-SoonTS
pubmed:issnType	Print
pubmed:volume	42
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	205-8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15591839-Animals, pubmed-meshheading:15591839-Apoptosis, pubmed-meshheading:15591839-Entamoeba histolytica, pubmed-meshheading:15591839-Host-Parasite Interactions, pubmed-meshheading:15591839-Humans, pubmed-meshheading:15591839-Neutrophils
pubmed:year	2004
pubmed:articleTitle	Ultrastructural observation of human neutrophils during apoptotic cell death triggered by Entamoeba histolytica.
pubmed:affiliation	Department of Parasitology, Institute of Tropical Medicine, and Brain Korea 21 for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.
pubmed:publicationType	Journal Article, In Vitro, Research Support, Non-U.S. Gov't