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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5703
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
306
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1930-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15591202-Amino Acid Motifs,
pubmed-meshheading:15591202-Amino Acid Sequence,
pubmed-meshheading:15591202-Animals,
pubmed-meshheading:15591202-Computational Biology,
pubmed-meshheading:15591202-Cytoplasm,
pubmed-meshheading:15591202-Erythrocyte Membrane,
pubmed-meshheading:15591202-Gene Expression Profiling,
pubmed-meshheading:15591202-Genes, Protozoan,
pubmed-meshheading:15591202-Humans,
pubmed-meshheading:15591202-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:15591202-Malaria, Falciparum,
pubmed-meshheading:15591202-Membrane Proteins,
pubmed-meshheading:15591202-Molecular Sequence Data,
pubmed-meshheading:15591202-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:15591202-Plasmodium,
pubmed-meshheading:15591202-Plasmodium falciparum,
pubmed-meshheading:15591202-Protein Sorting Signals,
pubmed-meshheading:15591202-Protein Transport,
pubmed-meshheading:15591202-Protozoan Proteins,
pubmed-meshheading:15591202-Recombinant Fusion Proteins,
pubmed-meshheading:15591202-Sequence Alignment,
pubmed-meshheading:15591202-Vacuoles,
pubmed-meshheading:15591202-Virulence,
pubmed-meshheading:15591202-Virulence Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Targeting malaria virulence and remodeling proteins to the host erythrocyte.
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pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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