Linked Life Data

15591118

Source:http://linkedlifedata.com/resource/pubmed/id/15591118

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-3-22
pubmed:abstractText
OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is transiently expressed on T cells after T-cell receptor (TCR) ligation. Both naive and activated CD4(+)CD25+ regulatory T cells (T reg's) express OX40 but its functional role has not been determined. Since glucocorticoid-induced tumor necrosis factor receptor (GITR), a related TNF receptor family member, influences T reg function, we tested whether OX40 might have similar effect. Triggering either GITR or OX40 on T reg's using agonist antibodies inhibited their capacity to suppress and restored effector T-cell proliferation, interleukin-2 (IL-2) gene transcription and cytokine production. OX40 abrogation of T reg suppression was confirmed in vivo in a model of graft-versus-host disease (GVHD). In a fully allogeneic C57BL/6>BALB/c bone marrow transplantation, GVHD was lethal unless T reg's were cotransferred with the bone marrow and effector T cells. Strikingly, T reg suppression of GVHD was abrogated either by intraperitoneal injection of anti-OX40 or anti-GITR monoclonal antibodies (mAbs) immediately after transfer, or by in vitro pretreatment of T reg's with the same mAbs before transfer. Cumulatively, the results suggest that in addition to controlling memory T-cell numbers, OX40 directly controls T reg-mediated suppression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2845-51
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15591118-Animals, pubmed-meshheading:15591118-Antibodies, Monoclonal, pubmed-meshheading:15591118-Bone Marrow Transplantation, pubmed-meshheading:15591118-CD4-Positive T-Lymphocytes, pubmed-meshheading:15591118-Cell Division, pubmed-meshheading:15591118-Glucocorticoid-Induced TNFR-Related Protein, pubmed-meshheading:15591118-Graft vs Host Disease, pubmed-meshheading:15591118-Interleukin-2, pubmed-meshheading:15591118-Lymphocyte Activation, pubmed-meshheading:15591118-Mice, pubmed-meshheading:15591118-Mice, Inbred BALB C, pubmed-meshheading:15591118-Mice, Inbred C57BL, pubmed-meshheading:15591118-Mice, Mutant Strains, pubmed-meshheading:15591118-Rats, pubmed-meshheading:15591118-Rats, Wistar, pubmed-meshheading:15591118-Receptors, Interleukin-2, pubmed-meshheading:15591118-Receptors, Nerve Growth Factor, pubmed-meshheading:15591118-Receptors, OX40, pubmed-meshheading:15591118-Receptors, Tumor Necrosis Factor
pubmed:year
2005
pubmed:articleTitle
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.
pubmed:affiliation
Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't