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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T) have intermediate activity and homozygotes for the variant allele (T/T) are deficient in NQO1 activity. In previous studies, genotypes conferring lower NQO1 activity have been associated with an increased risk of acute leukemia, particularly infant leukemia carrying MLL/AF4 fusion genes. In the present study, we investigated this association in our population and extended the analysis to other subgroups of pediatric hematologic neoplasms characterized by specific fusion genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/MLL-AF4 fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/NAD(P)H Dehydrogenase (Quinone),
http://linkedlifedata.com/resource/pubmed/chemical/NQO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Pesticides,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-AML1 fusion protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:BorkhardtArndtA,
pubmed-author:CarioGunnarG,
pubmed-author:ElsnerHolger-AndreasHA,
pubmed-author:HaasOskar AOA,
pubmed-author:HarbottJochenJ,
pubmed-author:KrachtThorbenT,
pubmed-author:LangerThorstenT,
pubmed-author:MarschalekRolfR,
pubmed-author:MetzlerMarkusM,
pubmed-author:ReiterAlfredA,
pubmed-author:ReppReinaldR,
pubmed-author:SchrappeMartinM,
pubmed-author:StanullaMartinM,
pubmed-author:StrehlSabineS,
pubmed-author:TsoiM MMM,
pubmed-author:ViehmannSusanneS,
pubmed-author:WelteKarlK
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1492-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15590400-Adolescent,
pubmed-meshheading:15590400-Adult,
pubmed-meshheading:15590400-Age Factors,
pubmed-meshheading:15590400-Aged,
pubmed-meshheading:15590400-Burkitt Lymphoma,
pubmed-meshheading:15590400-Cell Transformation, Neoplastic,
pubmed-meshheading:15590400-Child,
pubmed-meshheading:15590400-Child, Preschool,
pubmed-meshheading:15590400-Codon,
pubmed-meshheading:15590400-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:15590400-Female,
pubmed-meshheading:15590400-Fusion Proteins, bcr-abl,
pubmed-meshheading:15590400-Genotype,
pubmed-meshheading:15590400-Humans,
pubmed-meshheading:15590400-Infant,
pubmed-meshheading:15590400-Male,
pubmed-meshheading:15590400-Middle Aged,
pubmed-meshheading:15590400-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:15590400-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:15590400-Oncogene Proteins, Fusion,
pubmed-meshheading:15590400-Pesticides,
pubmed-meshheading:15590400-Polymorphism, Single Nucleotide,
pubmed-meshheading:15590400-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15590400-Risk
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pubmed:year |
2004
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pubmed:articleTitle |
NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.
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pubmed:affiliation |
Pediatric Hematology/Oncology, Medical School of Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Multicenter Study
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