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rdf:type |
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lifeskim:mentions |
umls-concept:C0018823,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035015,
umls-concept:C0038856,
umls-concept:C0085358,
umls-concept:C0086597,
umls-concept:C0162832,
umls-concept:C0205263,
umls-concept:C0332835,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1416467,
umls-concept:C1515895,
umls-concept:C1548437,
umls-concept:C1704410,
umls-concept:C1706438,
umls-concept:C1882923,
umls-concept:C2698600
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pubmed:issue |
4
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
Human CD8+ FOXP3+ T suppressor cells (TS) were previously shown to induce the expression of the inhibitory receptors, Immunoglobulin-like transcript (ILT) 3 and ILT4 on dendritic and endothelial cells, rendering them tolerogenic to allogeneic T cells. We have demonstrated the importance of CD8+ TS in a rat model of heart allo-transplantation. Tolerance was induced in ACI recipients by multiple transfusions of UVB-irradiated blood from Lewis heart donors. CD8+ T cells from tolerant ACI rats expressed FOXP3, transferred tolerance to naive secondary hosts and induced the upregulation of the inhibitory receptor, paired immunoglobulin-like receptor (PIR)-B, an ILT4 orthologue, in Lewis dendritic cells (DC) and heart endothelial cells (EC). When long-term surviving Lewis heart allografts with PIR-B+ EC were retransplanted from a primary to a secondary ACI recipient they did not elicit rejection. This study focuses attention on the need to develop agents that act directly on graft EC in order to achieve tolerance.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0966-3274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-47
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pubmed:dateRevised |
2008-10-10
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pubmed:meshHeading |
pubmed-meshheading:15589736-Animals,
pubmed-meshheading:15589736-Antigen-Presenting Cells,
pubmed-meshheading:15589736-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15589736-DNA-Binding Proteins,
pubmed-meshheading:15589736-Forkhead Transcription Factors,
pubmed-meshheading:15589736-Graft Rejection,
pubmed-meshheading:15589736-Heart Transplantation,
pubmed-meshheading:15589736-Immune Tolerance,
pubmed-meshheading:15589736-Male,
pubmed-meshheading:15589736-Rats,
pubmed-meshheading:15589736-Rats, Inbred ACI,
pubmed-meshheading:15589736-Rats, Inbred Lew,
pubmed-meshheading:15589736-Rats, Inbred WF,
pubmed-meshheading:15589736-Receptors, Immunologic,
pubmed-meshheading:15589736-Transcription Factors,
pubmed-meshheading:15589736-Transplantation, Homologous
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pubmed:year |
2004
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pubmed:articleTitle |
Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection.
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pubmed:affiliation |
Columbia University, Department of Pathology, 630 West 168th Street-P and S 14-401, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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