rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-13
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pubmed:abstractText |
Anaplastic large-cell lymphomas (ALCL) are frequently associated with the chromosomal translocation t(2;5) (p23;q35) resulting in the NPM/ALK fusion gene that encodes a constitutively activated tyrosine kinase. We showed that NPM/ALK stimulated cell proliferation and that PI-3K/AKT pathway played an important role in this effect. p27Kip1 is a member of the CDK family inhibitory proteins regulating the entry into S phase. It was reported that p27Kip1 function is impaired in many tumors. In this study we investigated the role of PI-3K/AKT in NPM/ALK-dependent downregulation of p27Kip1 protein.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/epoxomicin,
http://linkedlifedata.com/resource/pubmed/chemical/p80(NPM-ALK) protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1265-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15588951-B-Lymphocytes,
pubmed-meshheading:15588951-Blotting, Western,
pubmed-meshheading:15588951-Carrier Proteins,
pubmed-meshheading:15588951-Cell Line, Transformed,
pubmed-meshheading:15588951-Cell Line, Tumor,
pubmed-meshheading:15588951-Cell Nucleus,
pubmed-meshheading:15588951-Cell Proliferation,
pubmed-meshheading:15588951-Cell Transformation, Neoplastic,
pubmed-meshheading:15588951-Chromones,
pubmed-meshheading:15588951-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15588951-Down-Regulation,
pubmed-meshheading:15588951-Enzyme Inhibitors,
pubmed-meshheading:15588951-Gene Expression Regulation, Leukemic,
pubmed-meshheading:15588951-Hematopoietic Stem Cells,
pubmed-meshheading:15588951-Humans,
pubmed-meshheading:15588951-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15588951-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:15588951-Morpholines,
pubmed-meshheading:15588951-Oligopeptides,
pubmed-meshheading:15588951-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15588951-Phosphorylation,
pubmed-meshheading:15588951-Proteasome Endopeptidase Complex,
pubmed-meshheading:15588951-Protein Transport,
pubmed-meshheading:15588951-Protein-Tyrosine Kinases,
pubmed-meshheading:15588951-S Phase,
pubmed-meshheading:15588951-Signal Transduction,
pubmed-meshheading:15588951-Transformation, Genetic,
pubmed-meshheading:15588951-Translocation, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
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pubmed:affiliation |
College of Science and Technology, Center for Biotechnology, Temple University, Philadelphia, Pa. 19008, USA. aslupian@temple.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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