Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-12-13
pubmed:abstractText
Anaplastic large-cell lymphomas (ALCL) are frequently associated with the chromosomal translocation t(2;5) (p23;q35) resulting in the NPM/ALK fusion gene that encodes a constitutively activated tyrosine kinase. We showed that NPM/ALK stimulated cell proliferation and that PI-3K/AKT pathway played an important role in this effect. p27Kip1 is a member of the CDK family inhibitory proteins regulating the entry into S phase. It was reported that p27Kip1 function is impaired in many tumors. In this study we investigated the role of PI-3K/AKT in NPM/ALK-dependent downregulation of p27Kip1 protein.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz..., http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Chromones, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/epoxomicin, http://linkedlifedata.com/resource/pubmed/chemical/p80(NPM-ALK) protein
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1265-71
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15588951-B-Lymphocytes, pubmed-meshheading:15588951-Blotting, Western, pubmed-meshheading:15588951-Carrier Proteins, pubmed-meshheading:15588951-Cell Line, Transformed, pubmed-meshheading:15588951-Cell Line, Tumor, pubmed-meshheading:15588951-Cell Nucleus, pubmed-meshheading:15588951-Cell Proliferation, pubmed-meshheading:15588951-Cell Transformation, Neoplastic, pubmed-meshheading:15588951-Chromones, pubmed-meshheading:15588951-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:15588951-Down-Regulation, pubmed-meshheading:15588951-Enzyme Inhibitors, pubmed-meshheading:15588951-Gene Expression Regulation, Leukemic, pubmed-meshheading:15588951-Hematopoietic Stem Cells, pubmed-meshheading:15588951-Humans, pubmed-meshheading:15588951-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15588951-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:15588951-Morpholines, pubmed-meshheading:15588951-Oligopeptides, pubmed-meshheading:15588951-Phosphatidylinositol 3-Kinases, pubmed-meshheading:15588951-Phosphorylation, pubmed-meshheading:15588951-Proteasome Endopeptidase Complex, pubmed-meshheading:15588951-Protein Transport, pubmed-meshheading:15588951-Protein-Tyrosine Kinases, pubmed-meshheading:15588951-S Phase, pubmed-meshheading:15588951-Signal Transduction, pubmed-meshheading:15588951-Transformation, Genetic, pubmed-meshheading:15588951-Translocation, Genetic
pubmed:year
2004
pubmed:articleTitle
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
pubmed:affiliation
College of Science and Technology, Center for Biotechnology, Temple University, Philadelphia, Pa. 19008, USA. aslupian@temple.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't