Linked Life Data

15588678

Source:http://linkedlifedata.com/resource/pubmed/id/15588678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-12-13
pubmed:abstractText
Cochlospermum tinctorium A. Rich. (Cochlospermaceae) is a widely used medicinal plant in the West African country, Mali. An ethnopharmacological survey was conducted and 106 traditional practitioners interviewed. The roots were the part of the plant reported to be the most frequently used for medicinal purposes. The main indications were to treat jaundice (41), gastro intestinal diseases or ailments (28), malaria (12), schistosomiasis (10) and dysurea (6). A high-molecular weight water extract (25, 50 and 100 mg/kg, body weight) significantly inhibited HCl/ethanol-induced gastric lesions in mice. The extract showed DPPH-radical scavenging- and immunomodulating activities in vitro. The main components of the extract were identified as polysaccharides (59.3%) and polyphenols (9.3%). The polysaccharides were purified and characterised as highly complex pectic arabinogalactans type II. As parts of the polyphenol compounds gallotannins and ferulic acids were identified. This study shows that the polysaccharides are partly responsible for the bioactivities observed in vitro. Both polysaccharides and polyphenols may be responsible for the anti-ulcer activities observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-69
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15588678-Adjuvants, Immunologic, pubmed-meshheading:15588678-Animals, pubmed-meshheading:15588678-Anti-Ulcer Agents, pubmed-meshheading:15588678-Antimalarials, pubmed-meshheading:15588678-Bixaceae, pubmed-meshheading:15588678-Female, pubmed-meshheading:15588678-Flavonoids, pubmed-meshheading:15588678-Free Radical Scavengers, pubmed-meshheading:15588678-Gastrointestinal Diseases, pubmed-meshheading:15588678-Humans, pubmed-meshheading:15588678-Jaundice, pubmed-meshheading:15588678-Male, pubmed-meshheading:15588678-Mali, pubmed-meshheading:15588678-Medicine, African Traditional, pubmed-meshheading:15588678-Mice, pubmed-meshheading:15588678-Mice, Inbred ICR, pubmed-meshheading:15588678-Phenols, pubmed-meshheading:15588678-Plant Extracts, pubmed-meshheading:15588678-Polymers, pubmed-meshheading:15588678-Polyphenols, pubmed-meshheading:15588678-Polysaccharides, pubmed-meshheading:15588678-Questionnaires, pubmed-meshheading:15588678-Schistosomicides, pubmed-meshheading:15588678-Urination Disorders, pubmed-meshheading:15588678-Water
pubmed:year
2005
pubmed:articleTitle
Medicinal use of Cochlospermum tinctorium in Mali Anti-ulcer-, radical scavenging- and immunomodulating activities of polymers in the aqueous extract of the roots.
pubmed:affiliation
Department of Pharmacognosy, School of Pharmacy, PO Box 1068, Blindern, 0316 Oslo, Norway. c.s.nergard@farmasi.uio.no
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't