Linked Life Data

15588613

Source:http://linkedlifedata.com/resource/pubmed/id/15588613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-12-13
pubmed:abstractText
Recent theoretical and experimental work has suggested that spin echo (SE) functional MRI (fMRI) has improved localization of neural activity compared to gradient echo (GE) fMRI at high field strengths, albeit with a decrease in blood oxygenation level-dependent (BOLD) contrast. The present study investigated spatial and temporal variations in GE and SE fMRI at 3 T in response to a brief visual stimulus. The results demonstrate that SE BOLD contrast reaches its maximum amplitude more quickly than does GE contrast at long echo times. We have called this metric the peak hemodynamic activation time (PHAT). Because BOLD changes in response to increased neuronal activity occur earlier in the microvasculature and then later propagate into the venous compartment, these results provide further evidence that SE-based BOLD contrast provides superior localization to the site of activation at 3 T. Spatial overlay of SE and GE PHAT maps onto structural images reveal markedly different spatial profiles and further support the interpretation that shorter peak times correlate to improved spatial sensitivity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1053-8119
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-23
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time.
pubmed:affiliation
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.