Linked Life Data

15588586

Source:http://linkedlifedata.com/resource/pubmed/id/15588586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-12-13
pubmed:databankReference
pubmed:abstractText
The organization and expression of a putative serine/threonine kinase gene (designated hcstk), proposed to relate to a conserved eukaryotic signal transduction pathway, was characterized for the socio-economically important pathogen Haemonchus contortus (Nematoda). The entire hcstk gene is approximately 26.7 kb in size, has 26 exons and is inferred to produce multiple isoforms via alternative splicing in its N-terminal header and spacer domains. Comparison of hcstk with its Caenorhabditis elegans homologue, par-1, revealed major differences in genomic organization, exon number and inferred mRNA processing. The expression of hcstk transcripts was highest in the first- and late-fourth-stage larvae of the parasite compared with other developmental stages, somewhat distinct from par-1 in C. elegans. In spite of a substantial amino acid sequence identity in the functional domains between the predicted proteins HcSTK and PAR-1, overall, the findings suggest a unique functional role for each molecule.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
343
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15588586-Alternative Splicing, pubmed-meshheading:15588586-Animals, pubmed-meshheading:15588586-Base Sequence, pubmed-meshheading:15588586-Caenorhabditis elegans, pubmed-meshheading:15588586-Caenorhabditis elegans Proteins, pubmed-meshheading:15588586-Consensus Sequence, pubmed-meshheading:15588586-Contig Mapping, pubmed-meshheading:15588586-Exons, pubmed-meshheading:15588586-Gene Expression, pubmed-meshheading:15588586-Gene Expression Profiling, pubmed-meshheading:15588586-Genome, pubmed-meshheading:15588586-Haemonchus, pubmed-meshheading:15588586-Molecular Sequence Data, pubmed-meshheading:15588586-Protein Isoforms, pubmed-meshheading:15588586-Protein-Serine-Threonine Kinases, pubmed-meshheading:15588586-RNA Splice Sites, pubmed-meshheading:15588586-Sequence Analysis, DNA
pubmed:year
2004
pubmed:articleTitle
Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1.
pubmed:affiliation
Primary Industries Research Victoria (Animal Genetics and Genomics), 475 Mickleham Road, Attwood, Victoria 3049, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't