Source:http://linkedlifedata.com/resource/pubmed/id/15586666
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-12-9
|
| pubmed:abstractText |
The effects of a single intraperitoneal injection of a non-metabolizable glucose analog 2-deoxyglucose (2-DG, 500 mg/kg) on the levels of beta-APP expression, and phosphorylated and unphosphorylated tau protein in the rat cerebral cortex were investigated. The effects of 2-DG on the ultrastructure of cortical neurons with particular emphasis on the morphology of the Golgi apparatus, and on brain bioenergetics assessed by in vivo 31P-MRS technique were also evaluated. Seven and a half hours after injection of 2-deoxyglucose a significant increase in brain cortex beta-APP expression, increased tau phosphorylation, and a marked relative expansion of the trans- part of the Golgi intracellular secretory pathway in cortical neurons has been found. The changes of beta-APP expression and tau phosphorylation appeared within 1 h after 2-DG application and continued for at least 24 h. However, brain 31P resonance spectra remained unchanged for up to 7.5 h after 2-DG. It is suggested that the increase of beta-APP expression represents a response of brain tissues to 2-DG-evoked biochemical stress, while tau hyperphosphorylation and the change in Golgi morphology may be secondary phenomena.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0065-1400
|
| pubmed:author |
pubmed-author:FiedorowiczMichalM,
pubmed-author:Frontczak-BaniewiczMa?gorzataM,
pubmed-author:Gordon-KrajcerWandaW,
pubmed-author:GriebPawelP,
pubmed-author:Jasi?skiAndrzejA,
pubmed-author:KryczkaTomaszT,
pubmed-author:KulinowskiPiotrP,
pubmed-author:MajcherKatarzynaK,
pubmed-author:RybaMiroslaw SMS,
pubmed-author:Su?ekZenonZ,
pubmed-author:WalskiMicha?M
|
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
491-502
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15586666-Amyloid beta-Protein Precursor,
pubmed-meshheading:15586666-Analysis of Variance,
pubmed-meshheading:15586666-Animals,
pubmed-meshheading:15586666-Antimetabolites,
pubmed-meshheading:15586666-Cell Count,
pubmed-meshheading:15586666-Cerebral Cortex,
pubmed-meshheading:15586666-Deoxyglucose,
pubmed-meshheading:15586666-Golgi Apparatus,
pubmed-meshheading:15586666-Immunohistochemistry,
pubmed-meshheading:15586666-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15586666-Male,
pubmed-meshheading:15586666-Microscopy, Electron, Transmission,
pubmed-meshheading:15586666-Neurons,
pubmed-meshheading:15586666-Phosphorylation,
pubmed-meshheading:15586666-Rats,
pubmed-meshheading:15586666-Rats, Wistar,
pubmed-meshheading:15586666-Time Factors,
pubmed-meshheading:15586666-tau Proteins
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex.
|
| pubmed:affiliation |
Laboratory of Experimental Pharmacology, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland. pgrieb@cmdik.pan.pl
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|