Linked Life Data

15585917

Source:http://linkedlifedata.com/resource/pubmed/id/15585917

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-12-8
pubmed:abstractText
Dendritic cells (DC) are the most potent antigen-presenting cells and form a promising new treatment modality. Fully activated DC loaded with antigen are very useful in stimulating immune responses, in particular those to combat cancer. Immature DC can either cause immunological tolerance or induce regulatory T-cells, opening up future application in transplantation, autoimmunity, and perhaps chronic inflammation. For these clinical applications, generation of DC under Good Manufacturing Practice conditions and without the use of animal products is a main prerequisite. To date, there are many different DC culture protocols, which subsequently lead to different types of DC. Protocols differ not only in DC preparation techniques, but also many other variables, like maturation status, dose and timing interval, route of administration, and antigen loading. DC vaccination, although very promising, is far from standardized. In this chapter we discuss the usefulness of standardized clinical and immunological criteria and the need for careful study design to further optimize the use of dendritic cells and to unequivocally prove their efficacy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1543-1894
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-26
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Phenotypical and functional characterization of clinical-grade dendritic cells.
pubmed:affiliation
Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article, Review