| pubmed-article:15585834 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C1622572 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:15585834 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:15585834 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15585834 | pubmed:dateCreated | 2004-12-8 | lld:pubmed |
| pubmed-article:15585834 | pubmed:abstractText | Cbl-b negatively regulates CD28-dependent T cell activation. In this report, we tested the hypothesis that CD28 and CTLA-4 have opposite roles in tuning T cell activation threshold by controlling the levels of Cbl-b protein expression. We demonstrate that CD28 costimulation potentiates TCR-induced Cbl-b degradation, whereas CTLA-4-B7 interaction is required for Cbl-b re-expression. In support of this finding, Cbl-b expression in CTLA-4 knockout (KO) T cells is significantly reduced, and treating CTLA-4KO mice with human CTLA-4Ig to block CD28-B7 interaction restores Cbl-b expression on T cells. Furthermore, CD28 and CTLA-4 costimulatory effects are compromised in Cbl-bKO T cells. These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation. | lld:pubmed |
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| pubmed-article:15585834 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15585834 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15585834 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15585834 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15585834 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:ZhangJianJ | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:ChenLiepingL | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:GlantTibor... | lld:pubmed |
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| pubmed-article:15585834 | pubmed:author | pubmed-author:VermesCsabaC | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:GálIstvánI | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:ShaoQingQ | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:ChongAnita... | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:AlegreMaria-L... | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:LiDongdongD | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:KorenyTamasT | lld:pubmed |
| pubmed-article:15585834 | pubmed:author | pubmed-author:XuXuemeiX | lld:pubmed |
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| pubmed-article:15585834 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15585834 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:15585834 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15585834 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15585834 | pubmed:pagination | 7135-9 | lld:pubmed |
| pubmed-article:15585834 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15585834 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15585834 | pubmed:articleTitle | Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. | lld:pubmed |
| pubmed-article:15585834 | pubmed:affiliation | Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. | lld:pubmed |
| pubmed-article:15585834 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15585834 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15585834 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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