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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-12-7
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pubmed:abstractText |
The growth and metastasis of solid tumors are dependent on angiogenesis. Endostatin, the C-terminal proteolytic fragment of collagen XVIII, is a potent endogenous angiogenesis inhibitor. The authors designed a topical antiangiogenic gene therapy with recombinant human endostatin adenovirus (Ad-hEndo) and assessed its effects on the inhibition of angiogenesis in vitro, and tumor growth and metastasis in vivo.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1003-9406
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
557-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15583981-Adenoviridae,
pubmed-meshheading:15583981-Animals,
pubmed-meshheading:15583981-Cell Line, Tumor,
pubmed-meshheading:15583981-Cell Proliferation,
pubmed-meshheading:15583981-Cells, Cultured,
pubmed-meshheading:15583981-Disease Models, Animal,
pubmed-meshheading:15583981-Endostatins,
pubmed-meshheading:15583981-Endothelial Cells,
pubmed-meshheading:15583981-Gene Therapy,
pubmed-meshheading:15583981-Genetic Vectors,
pubmed-meshheading:15583981-Humans,
pubmed-meshheading:15583981-Kidney,
pubmed-meshheading:15583981-Mice,
pubmed-meshheading:15583981-Mice, Nude,
pubmed-meshheading:15583981-Neoplasm Metastasis,
pubmed-meshheading:15583981-Neoplasm Transplantation,
pubmed-meshheading:15583981-Neoplasms, Experimental,
pubmed-meshheading:15583981-Random Allocation,
pubmed-meshheading:15583981-Recombinant Proteins,
pubmed-meshheading:15583981-Transfection,
pubmed-meshheading:15583981-Umbilical Veins,
pubmed-meshheading:15583981-Xenograft Model Antitumor Assays
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pubmed:year |
2004
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pubmed:articleTitle |
[Inhibition of tumor growth and metastasis via local administration of recombinant human endostatin adenovirus].
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pubmed:affiliation |
Center for Biotherapy of Cancer and Cancer Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China.
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pubmed:publicationType |
Journal Article,
English Abstract
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