| pubmed-article:15583818 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15583818 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:15583818 | lifeskim:mentions | umls-concept:C0085171 | lld:lifeskim |
| pubmed-article:15583818 | lifeskim:mentions | umls-concept:C0205223 | lld:lifeskim |
| pubmed-article:15583818 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15583818 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:15583818 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15583818 | pubmed:dateCreated | 2004-12-7 | lld:pubmed |
| pubmed-article:15583818 | pubmed:abstractText | Aphidicolin, a tetracyclic diterpene antibiotic produced by Cephalosporium aphidicola, is under investigation as anti-cancer drug. Because of its poor solubility in water, it cannot be administered directly in vivo. Systemic application of aphidicolin glycinate or aphidicolin gamma-cyclodextrin complexes resulted in tumour growth inhibition but not in cures. To improve the pharmacokinetics, a liposomal preparation of aphidicolin was developed and tested in neuroblastoma-bearing (UKF-NB-3) mice. The loading capacity of these liposomes was limited. Therefore, 4.5 mg aphidicolin/kg body weight was the maximum aphidicolin dose that could be applied as liposomal preparation in this approach. Comparison of effects on tumour growth exhibited by aphidicolin liposomes (4.5 mg aphidicolin/kg) given for 15 consecutive days to those of gamma-cyclodextrin inclusion complexes (15 mg aphidicolin/kg) revealed comparable tumour growth inhibition, although aphidicolin concentrations were approximately 3-fold lower. This shows that liposomal encapsulation is a promising strategy for the improvement of systemic anti-cancer activity of aphidicolin. | lld:pubmed |
| pubmed-article:15583818 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15583818 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583818 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15583818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583818 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15583818 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15583818 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:15583818 | pubmed:author | pubmed-author:CinatlJindric... | lld:pubmed |
| pubmed-article:15583818 | pubmed:author | pubmed-author:CinatlJarosla... | lld:pubmed |
| pubmed-article:15583818 | pubmed:author | pubmed-author:MichaelisMart... | lld:pubmed |
| pubmed-article:15583818 | pubmed:author | pubmed-author:ZimmerAndreas... | lld:pubmed |
| pubmed-article:15583818 | pubmed:author | pubmed-author:HandjouNganou... | lld:pubmed |
| pubmed-article:15583818 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15583818 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:15583818 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15583818 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15583818 | pubmed:pagination | 157-60 | lld:pubmed |
| pubmed-article:15583818 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:meshHeading | pubmed-meshheading:15583818... | lld:pubmed |
| pubmed-article:15583818 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15583818 | pubmed:articleTitle | Increased systemic efficacy of aphidicolin encapsulated in liposomes. | lld:pubmed |
| pubmed-article:15583818 | pubmed:affiliation | Institut für Medizinische Virologie, Zentrum der Hygiene, Klinikum der J.W. Goethe-Universität, 40, 60596 Frankfurt am Main, Germany. | lld:pubmed |
| pubmed-article:15583818 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15583818 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15583818 | lld:pubmed |
