Source:http://linkedlifedata.com/resource/pubmed/id/15583818
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-12-7
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pubmed:abstractText |
Aphidicolin, a tetracyclic diterpene antibiotic produced by Cephalosporium aphidicola, is under investigation as anti-cancer drug. Because of its poor solubility in water, it cannot be administered directly in vivo. Systemic application of aphidicolin glycinate or aphidicolin gamma-cyclodextrin complexes resulted in tumour growth inhibition but not in cures. To improve the pharmacokinetics, a liposomal preparation of aphidicolin was developed and tested in neuroblastoma-bearing (UKF-NB-3) mice. The loading capacity of these liposomes was limited. Therefore, 4.5 mg aphidicolin/kg body weight was the maximum aphidicolin dose that could be applied as liposomal preparation in this approach. Comparison of effects on tumour growth exhibited by aphidicolin liposomes (4.5 mg aphidicolin/kg) given for 15 consecutive days to those of gamma-cyclodextrin inclusion complexes (15 mg aphidicolin/kg) revealed comparable tumour growth inhibition, although aphidicolin concentrations were approximately 3-fold lower. This shows that liposomal encapsulation is a promising strategy for the improvement of systemic anti-cancer activity of aphidicolin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1021-335X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15583818-Animals,
pubmed-meshheading:15583818-Antibiotics, Antineoplastic,
pubmed-meshheading:15583818-Aphidicolin,
pubmed-meshheading:15583818-Drug Carriers,
pubmed-meshheading:15583818-Female,
pubmed-meshheading:15583818-Humans,
pubmed-meshheading:15583818-Liposomes,
pubmed-meshheading:15583818-Mice,
pubmed-meshheading:15583818-Mice, Nude,
pubmed-meshheading:15583818-Neoplasm Transplantation,
pubmed-meshheading:15583818-Neuroblastoma,
pubmed-meshheading:15583818-Tumor Cells, Cultured
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pubmed:year |
2005
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pubmed:articleTitle |
Increased systemic efficacy of aphidicolin encapsulated in liposomes.
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pubmed:affiliation |
Institut für Medizinische Virologie, Zentrum der Hygiene, Klinikum der J.W. Goethe-Universität, 40, 60596 Frankfurt am Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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