|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2004-12-7
|
|
pubmed:abstractText |
Depolarisation of the plasma membrane has been shown to be actively regulated during lymphocyte-apoptosis. Here, we present data about anti-Fas and As2O3 induced depolarisation of myeloid U-937 cells. Anti-Fas but not As2O3-induced depolarisation was significantly dependent on caspase-activation. Na+-fluxes contributed to the depolarisation in early stages of As2O3-induced apoptosis, whereas the membrane potential in late stages depended on Cl- -fluxes. Cl- -channels also played an important role in the induction of cell shrinkage in As2O3-induced apoptosis. However, none of these ions contributed significantly to anti-Fas induced depolarisation. This indicates the existence of different mechanisms for apoptotic plasma membrane depolarisation within one cell type.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-Diisothiocyanostilbene-2,2'-Dis...,
http://linkedlifedata.com/resource/pubmed/chemical/5-nitro-2-(3-phenylpropylamino)benzo...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Arsenicals,
http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/anti-Fas monoclonal antibody,
http://linkedlifedata.com/resource/pubmed/chemical/arsenic trioxide
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
578
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
85-9
|
|
pubmed:dateRevised |
2005-9-1
|
|
pubmed:meshHeading |
pubmed-meshheading:15581621-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid,
pubmed-meshheading:15581621-Antibodies, Monoclonal,
pubmed-meshheading:15581621-Antigens, CD95,
pubmed-meshheading:15581621-Antineoplastic Agents,
pubmed-meshheading:15581621-Apoptosis,
pubmed-meshheading:15581621-Arsenicals,
pubmed-meshheading:15581621-Cell Membrane,
pubmed-meshheading:15581621-Chloride Channels,
pubmed-meshheading:15581621-Chlorides,
pubmed-meshheading:15581621-Humans,
pubmed-meshheading:15581621-Membrane Potentials,
pubmed-meshheading:15581621-Myeloid Cells,
pubmed-meshheading:15581621-Nitrobenzoates,
pubmed-meshheading:15581621-Oxides,
pubmed-meshheading:15581621-Sodium,
pubmed-meshheading:15581621-U937 Cells
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells.
|
|
pubmed:affiliation |
Department of Transfusion Medicine, University of Ulm, Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, Germany.
|
|
pubmed:publicationType |
Journal Article
|
