Linked Life Data

15580653

Source:http://linkedlifedata.com/resource/pubmed/id/15580653

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pubmed-article:15580653pubmed:abstractTextChronically HIV-1-infected patients fail to contain their viremia despite high frequencies of HIV-1-specific, IFN-gamma-producing CD8(+) T cells. However, these cells are known to exhibit both phenotypic and functional defects. We tested if mature dendritic cells (DC) could correct defective HIV-1 gag-specific T cell responses and if responses to other viral antigens were comparably affected. The circulating gag-specific CD8(+) T cells in fresh blood reliably produced IFN-gamma but lacked IL-2 and high perforin levels and failed to expand significantly during culture with mature DC presenting HIV-1 gag peptides. In contrast, CD8(+) T cells from long-term nonprogressors contained gag-specific IFN-gamma and IL-2 double producers, and the numbers of IFN-gamma producers expanded approximately 15-fold during culture with DC. DC from chronically infected patients could expand IFN-gamma- and IL-2-producing cells specific for influenza, cytomegalovirus and Epstein Barr virus, and the expansions were comparable to those in healthy donors. When the proliferative capacity of CD8(+) T cells from progressor patients was assessed by CFSE dilution, proliferation to other viral antigens was more vigorous than to HIV-1 gag. Therefore, monocyte-derived DC from HIV patients present viral antigens effectively, but there is a selective inability to expand CD8(+) IFN-gamma-producing and IFN-gamma and IL-2 double-producing T cells when challenged with HIV-1 gag.lld:pubmed
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pubmed-article:15580653pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15580653pubmed:articleTitleCD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses.lld:pubmed
pubmed-article:15580653pubmed:affiliationLaboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA.lld:pubmed
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pubmed-article:15580653pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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