Source:http://linkedlifedata.com/resource/pubmed/id/15580653
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rdf:type | |
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0025260,
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0042776,
umls-concept:C0085358,
umls-concept:C0205245,
umls-concept:C0328767,
umls-concept:C0805586,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1705180,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-3
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pubmed:abstractText |
Chronically HIV-1-infected patients fail to contain their viremia despite high frequencies of HIV-1-specific, IFN-gamma-producing CD8(+) T cells. However, these cells are known to exhibit both phenotypic and functional defects. We tested if mature dendritic cells (DC) could correct defective HIV-1 gag-specific T cell responses and if responses to other viral antigens were comparably affected. The circulating gag-specific CD8(+) T cells in fresh blood reliably produced IFN-gamma but lacked IL-2 and high perforin levels and failed to expand significantly during culture with mature DC presenting HIV-1 gag peptides. In contrast, CD8(+) T cells from long-term nonprogressors contained gag-specific IFN-gamma and IL-2 double producers, and the numbers of IFN-gamma producers expanded approximately 15-fold during culture with DC. DC from chronically infected patients could expand IFN-gamma- and IL-2-producing cells specific for influenza, cytomegalovirus and Epstein Barr virus, and the expansions were comparable to those in healthy donors. When the proliferative capacity of CD8(+) T cells from progressor patients was assessed by CFSE dilution, proliferation to other viral antigens was more vigorous than to HIV-1 gag. Therefore, monocyte-derived DC from HIV patients present viral antigens effectively, but there is a selective inability to expand CD8(+) IFN-gamma-producing and IFN-gamma and IL-2 double-producing T cells when challenged with HIV-1 gag.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15580653-Antigen Presentation,
pubmed-meshheading:15580653-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15580653-Case-Control Studies,
pubmed-meshheading:15580653-Cell Differentiation,
pubmed-meshheading:15580653-Dendritic Cells,
pubmed-meshheading:15580653-Gene Products, gag,
pubmed-meshheading:15580653-HIV Antigens,
pubmed-meshheading:15580653-HIV Infections,
pubmed-meshheading:15580653-HIV Seronegativity,
pubmed-meshheading:15580653-HIV-1,
pubmed-meshheading:15580653-Humans,
pubmed-meshheading:15580653-Immunologic Memory,
pubmed-meshheading:15580653-Interferon-gamma,
pubmed-meshheading:15580653-Interleukin-2,
pubmed-meshheading:15580653-Lymphocyte Activation,
pubmed-meshheading:15580653-Membrane Glycoproteins,
pubmed-meshheading:15580653-Perforin,
pubmed-meshheading:15580653-Pore Forming Cytotoxic Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
CD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses.
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pubmed:affiliation |
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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