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rdf:type |
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0017337,
umls-concept:C0271650,
umls-concept:C0439836,
umls-concept:C0681842,
umls-concept:C1412082,
umls-concept:C1416578,
umls-concept:C1659987,
umls-concept:C1706420,
umls-concept:C1711254,
umls-concept:C1882417
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pubmed:issue |
12
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pubmed:dateCreated |
2004-12-6
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pubmed:abstractText |
Type 2 diabetes is caused by defective insulin secretion and impaired insulin action. We investigated whether common polymorphisms in the SUR1 and Kir6.2 genes are associated with increased risk of type 2 diabetes in 490 subjects with impaired glucose tolerance participating in the Finnish Diabetes Prevention Study. The 1273AGA allele of the SUR1 gene was associated with a 2-fold risk of type 2 diabetes [odds ratio (OR), 2.00; 95% confidence interval (CI), 1.19-3.36; P = 0.009]. This silent polymorphism was in linkage disequilibrium with three promoter polymorphisms (G-2886A, G-1561A, and A-1273G), and they formed a high-risk haplotype having a 2-fold risk of type 2 diabetes (OR, 1.89; 95% CI, 1.09-3.27; P = 0.023). Subjects with both the high-risk haplotype of the SUR1 gene and the 23K allele of the Kir6.2 gene had a 6-fold risk for the conversion to diabetes compared with those without any of these risk genotypes (OR, 5.68; 95% CI, 1.75-18.32; P = 0.004). We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine,
http://linkedlifedata.com/resource/pubmed/chemical/Kir6.2 channel,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-972X
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pubmed:author |
pubmed-author:ErikssonJohanJ,
pubmed-author:Finnish Diabetes Prevention Study Group,
pubmed-author:HämäläinenHelenaH,
pubmed-author:Ilanne-ParikkaPirjoP,
pubmed-author:Keinänen-KiukaanniemiSirkkaS,
pubmed-author:LaaksoMarkkuM,
pubmed-author:LaukkanenOlliO,
pubmed-author:LindströmJaanaJ,
pubmed-author:PihlajamäkiJussiJ,
pubmed-author:TuomilehtoJaakkoJ,
pubmed-author:UusitupaMattiM,
pubmed-author:ValleTimo TTT
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6286-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15579791-ATP-Binding Cassette Transporters,
pubmed-meshheading:15579791-Adenine,
pubmed-meshheading:15579791-Adult,
pubmed-meshheading:15579791-Alleles,
pubmed-meshheading:15579791-Confidence Intervals,
pubmed-meshheading:15579791-Diabetes Mellitus, Type 2,
pubmed-meshheading:15579791-Disease Progression,
pubmed-meshheading:15579791-Genetic Predisposition to Disease,
pubmed-meshheading:15579791-Glucose Intolerance,
pubmed-meshheading:15579791-Guanine,
pubmed-meshheading:15579791-Haplotypes,
pubmed-meshheading:15579791-Humans,
pubmed-meshheading:15579791-Linkage Disequilibrium,
pubmed-meshheading:15579791-Lysine,
pubmed-meshheading:15579791-Middle Aged,
pubmed-meshheading:15579791-Odds Ratio,
pubmed-meshheading:15579791-Polymorphism, Genetic,
pubmed-meshheading:15579791-Potassium Channels,
pubmed-meshheading:15579791-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:15579791-Promoter Regions, Genetic,
pubmed-meshheading:15579791-Receptors, Drug
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pubmed:year |
2004
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pubmed:articleTitle |
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.
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pubmed:affiliation |
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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