Source:http://linkedlifedata.com/resource/pubmed/id/15579225
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-12-6
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| pubmed:abstractText |
The retinal dopaminergic system is a global regulator of retinal function. Apart from the fact that the rates of dopamine synthesis and release are increased by increasing illumination, the visual image parameters that influence dopaminergic function are mostly unknown. Roles for spatial and temporal frequency and image contrast are suggested by the effects of form-deprivation with a diffusing goggle. Form-deprivation reduces the rates of dopamine synthesis and release, and induces myopia, which is prevented by dopamine agonists. Our purpose here was to identify visual stimulus parameters that activate dopaminergic amacrine cells and elicit dopamine release. White Leghorn cockerels 4-7 days old were exposed to 2 h of form-deprivation, reduced light intensity, or stimuli of varied temporal or spatial frequency. Activation of dopaminergic neurons, labeled for tyrosine hydroxylase (TH), was assessed with immunocytochemistry for c-Fos, and dopamine release was measured by HPLC analysis of dopamine metabolite accumulation in the vitreous body. Form-deprivation did not reduce TH+ cell activation or vitreal dopamine metabolite accumulation any more than did neutral-density filters of approximately equal transmittance. TH+ cell activation and vitreal metabolite accumulation were not affected significantly by exposure to 2, 5, 10, 15, or 20 Hz stroboscopic stimulation on a dark background, or by sine-wave gratings of 0.089, 0.44, 0.89, 1.04, or 3.13 cycles/deg compared to a uniform gray target of equal mean luminance. These data indicate that the retinal dopaminergic system does not respond readily to short-term changes in visual stimulus parameters, other than light intensity, under the conditions of these experiments.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0952-5238
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
627-35
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| pubmed:meshHeading |
pubmed-meshheading:15579225-Amacrine Cells,
pubmed-meshheading:15579225-Animals,
pubmed-meshheading:15579225-Animals, Newborn,
pubmed-meshheading:15579225-Chickens,
pubmed-meshheading:15579225-Dopamine,
pubmed-meshheading:15579225-Eyeglasses,
pubmed-meshheading:15579225-Filtration,
pubmed-meshheading:15579225-Light,
pubmed-meshheading:15579225-Male,
pubmed-meshheading:15579225-Photic Stimulation,
pubmed-meshheading:15579225-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15579225-Sensory Deprivation,
pubmed-meshheading:15579225-Time Factors,
pubmed-meshheading:15579225-Tyrosine 3-Monooxygenase
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| pubmed:articleTitle |
Spatial, temporal, and intensive determinants of dopamine release in the chick retina.
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| pubmed:affiliation |
Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
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| pubmed:publicationType |
Journal Article
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