Source:http://linkedlifedata.com/resource/pubmed/id/15578704
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-2-15
|
| pubmed:abstractText |
p73, a structural and functional homologue of p53, shares some p53-like tumor suppressor activity but also possesses oncogenic activity. Therefore, p73 plays an important role in modulating cell-cycle control and apoptosis. A potentially functional dinucleotide polymorphism, G4C14-to-A4T14, has been identified in the 5' untranslated region (UTR) of exon 2 of the p73 gene, which may theoretically form a stem-loop structure and affect gene expression. To test the hypothesis that these 2 common variants play a role in lung cancer susceptibility, we conducted a case-control study of 425 lung cancer patients and 588 cancer-free controls frequency-matched to the cases on age and sex in a Chinese population. The results showed that these 2 polymorphisms were in complete linkage disequilibrium and the frequencies of variant p73 AT haplotype (A4T14) were less common in the cases (0.225) than in the controls (0.287) (p = 0.0018), suggesting that this AT haplotype was protective against lung cancer. Compared to the p73 GC/GC homozygotes, both the AT/AT variant homozygotes and GC/AT heterozygotes were associated with a significantly decreased risk (adjusted OR: 0.45, 95% CI: 0.26-0.80 and OR: 0.70, 95% CI: 0.53-0.92, respectively). These results suggest that this p73 dinucleotide polymorphism may have a role in lung cancer susceptibility in our study population. Further studies are needed to elucidate potential functional relevance of the p73 AT variant allele.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2004 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
455-60
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:15578704-Aged,
pubmed-meshheading:15578704-Base Sequence,
pubmed-meshheading:15578704-Case-Control Studies,
pubmed-meshheading:15578704-China,
pubmed-meshheading:15578704-DNA-Binding Proteins,
pubmed-meshheading:15578704-Female,
pubmed-meshheading:15578704-Genes, Tumor Suppressor,
pubmed-meshheading:15578704-Humans,
pubmed-meshheading:15578704-Linkage Disequilibrium,
pubmed-meshheading:15578704-Lung Neoplasms,
pubmed-meshheading:15578704-Male,
pubmed-meshheading:15578704-Middle Aged,
pubmed-meshheading:15578704-Molecular Sequence Data,
pubmed-meshheading:15578704-Nuclear Proteins,
pubmed-meshheading:15578704-Odds Ratio,
pubmed-meshheading:15578704-Polymorphism, Genetic,
pubmed-meshheading:15578704-Risk Factors,
pubmed-meshheading:15578704-Tumor Suppressor Proteins
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population.
|
| pubmed:affiliation |
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|