Source:http://linkedlifedata.com/resource/pubmed/id/15575380
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2004-12-3
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pubmed:abstractText |
Morphine was administered intraperitoneally to Wistar rats at increasing doses from 10 to 60 mg pay during 8 days. Cardiomyocyte damage in the form of myocytolysis and wave-like deformations of muscle fibers prevailed at the level of light microscopy. Microcirculatory alterations were characteristic: stasis, sludge-phenomenon, perivascular and interstitial oedema, diapedes hemorrhages, focal proliferation of vascular wall cells. Ultrastructural lesions were as follows: subsarcolemma edema, mitochondrial destruction, formation of giant forms of mitochondria, single contractures, increasing micropinocytosis, intestitial edema.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0004-1955
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15575380-Animals,
pubmed-meshheading:15575380-Male,
pubmed-meshheading:15575380-Microcirculation,
pubmed-meshheading:15575380-Microscopy, Electron, Transmission,
pubmed-meshheading:15575380-Mitochondria, Heart,
pubmed-meshheading:15575380-Morphine,
pubmed-meshheading:15575380-Morphine Dependence,
pubmed-meshheading:15575380-Muscle Fibers, Skeletal,
pubmed-meshheading:15575380-Myocardium,
pubmed-meshheading:15575380-Myocytes, Cardiac,
pubmed-meshheading:15575380-Rats,
pubmed-meshheading:15575380-Rats, Wistar
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pubmed:articleTitle |
[Morphological alterations of the rat myocardium in chronic morphine intoxication].
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pubmed:publicationType |
Journal Article,
English Abstract
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