Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-12-2
pubmed:abstractText
Chronic psychoemotional stress of social defeats produces development of experimental anxious depression in male mice similar to this disorder in humans. 5-HT and 5-HIAA levels, TPH and MAO A activities, 5-HT1A-receptors in different brain areas were investigated at different stages of development of experimental disorder. It has been shown that initial stage (3 days of social stress) is accompanied by increase of 5-HT level in some brain areas. Decreased 5-HIAA levels in the hippocampus, amygdala and nucleus accumbens were discovered at the stage of forming depression (10 days of social stress). Pharmacological desensitisation and decreased number of 5-HT1A-receptors were shown in frontal cortex and amygdala. At the stage of pronounced depression (20 days of stress), there were no differences in 5-HT and 5-HIAA levels in all brain areas (excluding hypothalamus) of depressive animals. However increased number of 5-HT1A-receptors and decreased affinity in amygdala and decreased TPH and MAOA activities in hippocampus were found in depressive mice. Hypofunction of serotonergic system is suggested at the stage of pronounced depression state in animals. Similar processes had place in brain dopaminergic systems. It is concluded that dynamic changes of brain monoaminergic activities accompany the development of anxious depression in animals. Various parameters of monoaminergic systems are differently changed depending on brain area, mediator system and stage of disorder.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-1798
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-40
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15573884-Amygdala, pubmed-meshheading:15573884-Animals, pubmed-meshheading:15573884-Brain, pubmed-meshheading:15573884-Depression, pubmed-meshheading:15573884-Disease Models, Animal, pubmed-meshheading:15573884-Dopamine, pubmed-meshheading:15573884-Hippocampus, pubmed-meshheading:15573884-Hydroxyindoleacetic Acid, pubmed-meshheading:15573884-Male, pubmed-meshheading:15573884-Mice, pubmed-meshheading:15573884-Mice, Inbred C57BL, pubmed-meshheading:15573884-Monoamine Oxidase, pubmed-meshheading:15573884-Nucleus Accumbens, pubmed-meshheading:15573884-Receptor, Serotonin, 5-HT1A, pubmed-meshheading:15573884-Serotonin, pubmed-meshheading:15573884-Serotonin 5-HT1 Receptor Antagonists, pubmed-meshheading:15573884-Serotonin Agents, pubmed-meshheading:15573884-Tryptophan Hydroxylase
pubmed:articleTitle
[Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Review