| pubmed-article:15573474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0026239 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0014272 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0311404 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C1999146 | lld:lifeskim |
| pubmed-article:15573474 | lifeskim:mentions | umls-concept:C0443281 | lld:lifeskim |
| pubmed-article:15573474 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15573474 | pubmed:dateCreated | 2004-12-2 | lld:pubmed |
| pubmed-article:15573474 | pubmed:abstractText | Dexamethasone--a potent synthetic glucocorticoid--has multiple therapeutic applications and is used in all age groups, as well as for antenatal and perinatal treatments. However, side-effects of dexamethasone treatment, including those on development, are becoming increasingly apparent. Since developmental processes are energy-dependent, we examined the effects of chronic dexamethasone treatment on oxidative energy metabolism in liver mitochondria from rats belonging to different developmental age groups. Dexamethasone treatment adversely affected the state 3 respiration rates in 2- and 3-week groups and in the adults with glutamate as the substrates, whereas for pyruvate + malate, the adverse effects were seen for the 3 week and the adult groups. Oxidation of succinate was severely impaired in all the age groups. For ascorbate + TMPD as the substrate, elevated respiration was noted for the 5-week group and the impaired oxidation was observed in adults. Dexamethasone treatment also resulted in site-specific uncoupling with the effect being seen predominantly in the 3- and 5-week and adult animals. The activity of dehydrogenases decreased in a manner comparable to the respiration rates. The mitochondrial cytochromes decreased in an age-dependent manner. The ATPase activity also decreased significantly. The results thus emphasize the adverse effects of dexamethasone treatment on mitochondrial energy metabolism especially in critical age groups. | lld:pubmed |
| pubmed-article:15573474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15573474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15573474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15573474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15573474 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15573474 | pubmed:issn | 0148-0545 | lld:pubmed |
| pubmed-article:15573474 | pubmed:author | pubmed-author:KatyareSurend... | lld:pubmed |
| pubmed-article:15573474 | pubmed:author | pubmed-author:PandyaJignesh... | lld:pubmed |
| pubmed-article:15573474 | pubmed:author | pubmed-author:AgarwalNeeraj... | lld:pubmed |
| pubmed-article:15573474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15573474 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:15573474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15573474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15573474 | pubmed:pagination | 389-403 | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:meshHeading | pubmed-meshheading:15573474... | lld:pubmed |
| pubmed-article:15573474 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15573474 | pubmed:articleTitle | Effect of dexamethasone treatment on oxidative energy metabolism in rat liver mitochondria during postnatal developmental periods. | lld:pubmed |
| pubmed-article:15573474 | pubmed:affiliation | Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. jdpandya@buffalo.edu | lld:pubmed |
| pubmed-article:15573474 | pubmed:publicationType | Journal Article | lld:pubmed |
