Linked Life Data

15573474

Source:http://linkedlifedata.com/resource/pubmed/id/15573474

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-12-2
pubmed:abstractText
Dexamethasone--a potent synthetic glucocorticoid--has multiple therapeutic applications and is used in all age groups, as well as for antenatal and perinatal treatments. However, side-effects of dexamethasone treatment, including those on development, are becoming increasingly apparent. Since developmental processes are energy-dependent, we examined the effects of chronic dexamethasone treatment on oxidative energy metabolism in liver mitochondria from rats belonging to different developmental age groups. Dexamethasone treatment adversely affected the state 3 respiration rates in 2- and 3-week groups and in the adults with glutamate as the substrates, whereas for pyruvate + malate, the adverse effects were seen for the 3 week and the adult groups. Oxidation of succinate was severely impaired in all the age groups. For ascorbate + TMPD as the substrate, elevated respiration was noted for the 5-week group and the impaired oxidation was observed in adults. Dexamethasone treatment also resulted in site-specific uncoupling with the effect being seen predominantly in the 3- and 5-week and adult animals. The activity of dehydrogenases decreased in a manner comparable to the respiration rates. The mitochondrial cytochromes decreased in an age-dependent manner. The ATPase activity also decreased significantly. The results thus emphasize the adverse effects of dexamethasone treatment on mitochondrial energy metabolism especially in critical age groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-403
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effect of dexamethasone treatment on oxidative energy metabolism in rat liver mitochondria during postnatal developmental periods.
pubmed:affiliation
Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India. jdpandya@buffalo.edu
pubmed:publicationType
Journal Article