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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-6
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pubmed:abstractText |
Repeat length of the CAG microsatellite polymorphism in exon 1 of the androgen receptor (AR) gene has been associated with risk of prostate cancer in humans. This association has been the focus of >20 primary epidemiological publications and multiple review articles, but a consistent and reproducible association has yet to be confirmed. We systematically addressed possible causes of false-negative and false-positive association in >4,000 individuals from a multiethnic, prospective cohort study of prostate cancer, comprehensively studying genetic variation by microsatellite genotyping, direct resequencing of exons in advanced cancer cases, and haplotype analysis across the 180-kb AR genomic locus. These data failed to confirm that common genetic variation in the AR gene locus influences risk of prostate cancer. A systematic approach that assesses both coding and noncoding genetic variation in large and diverse patient samples can help clarify hypotheses about association between genetic variants and disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10234512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10344215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10364535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10502720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10574254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10695593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10706090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10794490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-10915221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11016637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11253062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11550169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11571725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11595700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11720249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-11994226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12029063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12081759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12085963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12107441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12189490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12202654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12364414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12376473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12376504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12394768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12524541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-12790786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-14585317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-14691592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-14991867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-15026468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-15052270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-1740333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-7476138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-7728763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-8065934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-8252045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-8998186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-9067292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-9096391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-9875243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15570555-9933058
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15570555-Aged,
pubmed-meshheading:15570555-Base Sequence,
pubmed-meshheading:15570555-Cohort Studies,
pubmed-meshheading:15570555-Ethnic Groups,
pubmed-meshheading:15570555-Female,
pubmed-meshheading:15570555-Genetic Variation,
pubmed-meshheading:15570555-Haplotypes,
pubmed-meshheading:15570555-Humans,
pubmed-meshheading:15570555-Linkage Disequilibrium,
pubmed-meshheading:15570555-Male,
pubmed-meshheading:15570555-Microsatellite Repeats,
pubmed-meshheading:15570555-Middle Aged,
pubmed-meshheading:15570555-Polymorphism, Single Nucleotide,
pubmed-meshheading:15570555-Prospective Studies,
pubmed-meshheading:15570555-Prostatic Neoplasms,
pubmed-meshheading:15570555-Receptors, Androgen,
pubmed-meshheading:15570555-Risk
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pubmed:year |
2005
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pubmed:articleTitle |
Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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