Linked Life Data

15570031

Source:http://linkedlifedata.com/resource/pubmed/id/15570031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-11-30
pubmed:abstractText
We investigated the effect of leucine supplementation on protein metabolism in skin wounds and muscle in anesthetized rabbits. l-[ring-(13)C(6)]phenylalanine was infused on d 7 after the ear was scalded, and the scalded ear and uninjured hindlimb were used as arteriovenous units to reflect protein kinetics in skin wounds and muscle. In comparison with a commercially available amino acid solution (10% Travasol), isonitrogenous [1638 micromol/(kg . h)] infusion of the amino acid solution with supplemental leucine to account for 35% of total nitrogen increased the net phenylalanine balance (P < 0.05) in the skin wound and muscle from -6.7 +/- 6.1 to 0.9 +/- 1.4 and from -4.4 +/- 2.4 to -1.0 +/- 0.4 micromol/(100 g . h), respectively. Infusion of leucine alone did not significantly improve the net phenylalanine balance in either skin wounds [-4.0 +/- 4.6 micromol/(100 g . h)] or muscle [-2.7 +/- 0.7 micromol/(100 g . h)]. We conclude that leucine supplementation had an anabolic effect on proteins in skin wounds and muscle, provided that adequate additional amino acids were also available.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3313-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Leucine supplementation has an anabolic effect on proteins in rabbit skin wound and muscle.
pubmed:affiliation
Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't