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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2004-11-30
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pubmed:abstractText |
Methylenetetrahydrofolate reductase (MTHFR) directs intracellular folate toward homocysteine metabolism and away from nucleotide synthesis. Two common MTHFR polymorphisms, C677T and A1298C, are associated with reduced enzyme activity. We evaluated the association of these polymorphisms with risk of relapse and bcr-abl mRNA transcript detection among 336 Caucasian patients who underwent allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7592-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15569990-Adolescent,
pubmed-meshheading:15569990-Adult,
pubmed-meshheading:15569990-Aged,
pubmed-meshheading:15569990-Cohort Studies,
pubmed-meshheading:15569990-Female,
pubmed-meshheading:15569990-Folic Acid,
pubmed-meshheading:15569990-Fusion Proteins, bcr-abl,
pubmed-meshheading:15569990-Genotype,
pubmed-meshheading:15569990-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15569990-Humans,
pubmed-meshheading:15569990-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:15569990-Male,
pubmed-meshheading:15569990-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:15569990-Middle Aged,
pubmed-meshheading:15569990-Polymorphism, Genetic,
pubmed-meshheading:15569990-Proportional Hazards Models,
pubmed-meshheading:15569990-Protein Binding,
pubmed-meshheading:15569990-RNA, Messenger,
pubmed-meshheading:15569990-Recurrence,
pubmed-meshheading:15569990-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15569990-Risk,
pubmed-meshheading:15569990-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Methylenetetrahydrofolate reductase genotype affects risk of relapse after hematopoietic cell transplantation for chronic myelogenous leukemia.
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pubmed:affiliation |
Cancer Prevention Program, Public Health Sciences Division and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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