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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-11-30
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pubmed:abstractText |
CC chemokines mediate leukocyte infiltration into inflamed tissue. We have recently shown that blockade of the CC chemokine receptor CCR1 reduces interstitial inflammation and fibrosis in murine obstructive nephropathy. However, it is not known whether CCR 1 blockade is protective in progressive renal injury associated with severe proteinuria. We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/BX 471,
http://linkedlifedata.com/resource/pubmed/chemical/Ccr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylurea Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2264-78
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15569315-Animals,
pubmed-meshheading:15569315-Antibiotics, Antineoplastic,
pubmed-meshheading:15569315-Chemokines,
pubmed-meshheading:15569315-Doxorubicin,
pubmed-meshheading:15569315-Fibrosis,
pubmed-meshheading:15569315-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:15569315-Kidney,
pubmed-meshheading:15569315-Leukocytes,
pubmed-meshheading:15569315-Male,
pubmed-meshheading:15569315-Mice,
pubmed-meshheading:15569315-Mice, Inbred BALB C,
pubmed-meshheading:15569315-Nephritis, Interstitial,
pubmed-meshheading:15569315-Nephrotic Syndrome,
pubmed-meshheading:15569315-Phenylurea Compounds,
pubmed-meshheading:15569315-Piperidines,
pubmed-meshheading:15569315-Proteinuria,
pubmed-meshheading:15569315-Receptors, CCR1,
pubmed-meshheading:15569315-Receptors, Chemokine
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pubmed:year |
2004
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pubmed:articleTitle |
CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome.
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pubmed:affiliation |
Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig-Maximilians-University, Munich, Germany. volker.vielhauer@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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