| pubmed-article:15568027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C0014836 | lld:lifeskim |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C1419789 | lld:lifeskim |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:15568027 | lifeskim:mentions | umls-concept:C1815389 | lld:lifeskim |
| pubmed-article:15568027 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15568027 | pubmed:dateCreated | 2004-12-21 | lld:pubmed |
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| pubmed-article:15568027 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568027 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568027 | pubmed:abstractText | Human healthy skin is continuously exposed to bacteria, but is particularly resistant to the common gut bacterium Escherichia coli. We show here that keratinocytes secrete, as the main E. coli-killing compound, the S100 protein psoriasin in vitro and in vivo in a site-dependent way. In vivo treatment of human skin with antibodies to psoriasin inhibited its E. coli-killing properties. Psoriasin was induced in keratinocytes in vitro and in vivo by E. coli, indicating that its focal expression in skin may derive from local microbial induction. Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli. | lld:pubmed |
| pubmed-article:15568027 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15568027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15568027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15568027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15568027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15568027 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15568027 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:ChristophersE... | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:SchröderJens-... | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:LangeHansH | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:HarderJürgenJ | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:GläserRegineR | lld:pubmed |
| pubmed-article:15568027 | pubmed:author | pubmed-author:BartelsJoachi... | lld:pubmed |
| pubmed-article:15568027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15568027 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15568027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15568027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15568027 | pubmed:pagination | 57-64 | lld:pubmed |
| pubmed-article:15568027 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15568027 | pubmed:meshHeading | pubmed-meshheading:15568027... | lld:pubmed |
| pubmed-article:15568027 | pubmed:meshHeading | pubmed-meshheading:15568027... | lld:pubmed |
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| pubmed-article:15568027 | pubmed:meshHeading | pubmed-meshheading:15568027... | lld:pubmed |
| pubmed-article:15568027 | pubmed:meshHeading | pubmed-meshheading:15568027... | lld:pubmed |
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| pubmed-article:15568027 | pubmed:meshHeading | pubmed-meshheading:15568027... | lld:pubmed |
| pubmed-article:15568027 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15568027 | pubmed:articleTitle | Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. | lld:pubmed |
| pubmed-article:15568027 | pubmed:affiliation | Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Germany. | lld:pubmed |
| pubmed-article:15568027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15568027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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