It has been suggested that genetic polymorphisms in certain glutathione-S-transferase (GST) genes reduce the effectiveness of detoxifying cytotoxins generated by chemotherapeutic agents, potentially resulting in enhanced clinical responses to chemotherapy.
Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA. gong.yang@vanderbilt.edu