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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2004-11-26
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pubmed:abstractText |
(E)-2-Acetyl-4-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4b) with a characteristic conformation and (E)-2-(2-morpholinocarbo-1-methylvinyl)-7-ethoxycarbopropoxybenzo[b]furan ((E)-3b) were prepared and evaluated for their leukotriene B4(LTB4) antagonistic activity. Compound 4b showed potent antagonistic activity against human BLT1 and BLT2 receptors. Compound (E)-3b displayed selective BLT2 receptor antagonistic activity. Both compounds were inactive to cysteinyl LT receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzofurans,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carbamates,
http://linkedlifedata.com/resource/pubmed/chemical/LTB4R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/LTB4R2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P2 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1477-0520
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pubmed:author |
pubmed-author:AndoKumikoK,
pubmed-author:AndoYukoY,
pubmed-author:KohnoShigekatsuS,
pubmed-author:KunitomoJun-ichiJ,
pubmed-author:NabeTakeshiT,
pubmed-author:OhishiYoshitakaY,
pubmed-author:OhtaShunsakuS,
pubmed-author:ShimizuTakaoT,
pubmed-author:TsujiErikoE,
pubmed-author:YamashitaMasayukiM,
pubmed-author:YokomizoTakehikoT
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3427-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15565232-Animals,
pubmed-meshheading:15565232-Benzofurans,
pubmed-meshheading:15565232-CHO Cells,
pubmed-meshheading:15565232-Calcium,
pubmed-meshheading:15565232-Calcium Signaling,
pubmed-meshheading:15565232-Carbamates,
pubmed-meshheading:15565232-Cricetinae,
pubmed-meshheading:15565232-Crystallography, X-Ray,
pubmed-meshheading:15565232-Gene Expression,
pubmed-meshheading:15565232-Humans,
pubmed-meshheading:15565232-Inhibitory Concentration 50,
pubmed-meshheading:15565232-Molecular Conformation,
pubmed-meshheading:15565232-Molecular Structure,
pubmed-meshheading:15565232-Morpholines,
pubmed-meshheading:15565232-Purinergic P2 Receptor Antagonists,
pubmed-meshheading:15565232-Receptors, Leukotriene B4,
pubmed-meshheading:15565232-Receptors, Purinergic P2
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pubmed:year |
2004
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pubmed:articleTitle |
Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors.
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pubmed:affiliation |
School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya, 663-8179, Japan.
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pubmed:publicationType |
Journal Article
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