Linked Life Data

15564581

Source:http://linkedlifedata.com/resource/pubmed/id/15564581

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
47
pubmed:dateCreated
2004-11-26
pubmed:abstractText
Typically, D1 and D2 dopamine (DA) receptors exert opposing actions on intracellular signaling molecules and often have disparate physiological effects; however, the factors determining preferential activation of D1 versus D2 signaling are not clear. Here, in vitro patch-clamp recordings show that DA concentration is a critical determinant of D1 versus D2 signaling in prefrontal cortex (PFC). Low DA concentrations (<500 nm) enhance IPSCs via D1 receptors, protein kinase A, and cAMP. Higher DA concentrations (>1 microm) decrease IPSCs via the following cascade: D2-->G(i)-->platelet-derived growth factor receptor--> increase phospholipase C--> increase IP3--> increase Ca2+--> decrease dopamine and cAMP-regulated phosphoprotein-32--> increase protein phosphatase 1/2A--> decrease GABA(A). Blockade of any molecule in the D2-linked pathway reveals a D1-mediated increase in IPSCs, suggesting that D1 effects are occluded at higher DA concentrations by this D2-mediated pathway. Thus, DA concentration, by acting through separate signaling cascades, may determine the relative amount of cortical inhibition and thereby differentially regulate the tuning of cortical networks.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10652-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15564581-Animals, pubmed-meshheading:15564581-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:15564581-Dopamine, pubmed-meshheading:15564581-Dose-Response Relationship, Drug, pubmed-meshheading:15564581-Electrophysiology, pubmed-meshheading:15564581-Mice, pubmed-meshheading:15564581-Mice, Inbred C57BL, pubmed-meshheading:15564581-Neural Inhibition, pubmed-meshheading:15564581-Patch-Clamp Techniques, pubmed-meshheading:15564581-Prefrontal Cortex, pubmed-meshheading:15564581-Pyramidal Cells, pubmed-meshheading:15564581-Rats, pubmed-meshheading:15564581-Rats, Sprague-Dawley, pubmed-meshheading:15564581-Receptors, Dopamine D1, pubmed-meshheading:15564581-Receptors, Dopamine D2, pubmed-meshheading:15564581-Signal Transduction, pubmed-meshheading:15564581-gamma-Aminobutyric Acid
pubmed:year
2004
pubmed:articleTitle
Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex.
pubmed:affiliation
Physiology and Neuroscience Department, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural