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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0026724,
umls-concept:C0035647,
umls-concept:C0086860,
umls-concept:C0205217,
umls-concept:C0913092,
umls-concept:C1518896,
umls-concept:C1706701,
umls-concept:C1882417
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pubmed:issue |
24
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pubmed:dateCreated |
2004-11-26
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pubmed:abstractText |
There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-10721994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-10721995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12176900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12190858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12797441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12815099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12949494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-12957386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-14499246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-1560346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-1661376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-2477702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-7986410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-8498644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-9012413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-9399875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-9521319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15564514-9836644
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:BuchbinderSusanS,
pubmed-author:CarringtonMaryM,
pubmed-author:DetelsRogerR,
pubmed-author:GoedertJames JJJ,
pubmed-author:HootsKeithK,
pubmed-author:HutchesonHolli BHB,
pubmed-author:LedermanMichael MMM,
pubmed-author:MartinMaureen PMP,
pubmed-author:NelsonGeorge WGW,
pubmed-author:O'BrienStephen JSJ,
pubmed-author:VlahovDavidD,
pubmed-author:van KooykYvetteY
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14053-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15564514-Cell Adhesion Molecules,
pubmed-meshheading:15564514-Cohort Studies,
pubmed-meshheading:15564514-HIV Infections,
pubmed-meshheading:15564514-HIV-1,
pubmed-meshheading:15564514-Humans,
pubmed-meshheading:15564514-Infusions, Parenteral,
pubmed-meshheading:15564514-Lectins, C-Type,
pubmed-meshheading:15564514-Mucous Membrane,
pubmed-meshheading:15564514-Polymorphism, Genetic,
pubmed-meshheading:15564514-Promoter Regions, Genetic,
pubmed-meshheading:15564514-Receptors, Cell Surface
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pubmed:year |
2004
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pubmed:articleTitle |
Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.
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pubmed:affiliation |
Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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