| pubmed-article:15564382 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C1835848 | lld:lifeskim |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C1159884 | lld:lifeskim |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:15564382 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:15564382 | pubmed:issue | Pt 25 | lld:pubmed |
| pubmed-article:15564382 | pubmed:dateCreated | 2004-11-26 | lld:pubmed |
| pubmed-article:15564382 | pubmed:abstractText | Adipocyte differentiation is controlled by complex actions involving gene expression and signal transduction. From metaphase to anaphase, peroxisome proliferator-activated receptor gamma, the CCAAT/enhancer-binding protein family and sterol regulatory element-binding protein-1 are known to function as master regulators. However, the mechanism underlying the earliest step, which triggers the initiation of differentiation, remains unknown. In previous reports, we have isolated a number of genes, whose expression increases in the early stage of differentiation in the mouse 3T3-L1 preadipocyte cell line. Here we report the cloning of the full-length cDNA and characterization of an unknown gene isolated previously and named fad24 (factor for adipocyte differentiation 24). Fad24 encodes a protein consisting of 807 amino acids. The deduced amino acid sequence was shown to have a basic leucine zipper motif and a NOC domain. Expression of fad24 was rapidly induced after stimulation with inducers. Furthermore, overexpression of fad24 in NIH-3T3 cells promoted adipogenesis in the presence of a ligand for peroxisome proliferator-activated receptor gamma. FAD24 localizes in the nucleus, especially within nuclear speckles. As the nuclear speckle functions as a nascent transcription and pre-mRNA splicing machinery, there is a possibility that FAD24 functions as one of the components for transcription and/or pre-mRNA splicing and positively regulates adipocyte differentiation. | lld:pubmed |
| pubmed-article:15564382 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15564382 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564382 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15564382 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15564382 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15564382 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15564382 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:15564382 | pubmed:author | pubmed-author:NishizukaMako... | lld:pubmed |
| pubmed-article:15564382 | pubmed:author | pubmed-author:ImagawaMasayo... | lld:pubmed |
| pubmed-article:15564382 | pubmed:author | pubmed-author:TominagaKeiK | lld:pubmed |
| pubmed-article:15564382 | pubmed:author | pubmed-author:JohmuraYoshik... | lld:pubmed |
| pubmed-article:15564382 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15564382 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15564382 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:15564382 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15564382 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15564382 | pubmed:pagination | 6217-26 | lld:pubmed |
| pubmed-article:15564382 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15564382 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15564382 | pubmed:articleTitle | Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. | lld:pubmed |
| pubmed-article:15564382 | pubmed:affiliation | Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. | lld:pubmed |
| pubmed-article:15564382 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15564382 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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