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rdf:type |
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0026845,
umls-concept:C0028580,
umls-concept:C0031715,
umls-concept:C0061418,
umls-concept:C0178666,
umls-concept:C0242485,
umls-concept:C0332120,
umls-concept:C0392756,
umls-concept:C0441655,
umls-concept:C1553628
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pubmed:issue |
4
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pubmed:dateCreated |
1992-5-4
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pubmed:abstractText |
To assess the rate-limiting step in muscle glycogen synthesis in non-insulin-dependent diabetes mellitus (NIDDM), the concentration of glucose-6-phosphate (G6P) was measured by 31P nuclear magnetic resonance (NMR) during a hyperglycemic-hyperinsulinemic clamp. Six subjects with NIDDM and six age weight-matched controls were studied at similar steady-state plasma concentrations of insulin (approximately 450 pmol/liter) and glucose (11 mmol/liter). The concentration of G6P in the gastrocnemius muscle was measured by 31P NMR. Whole-body oxidative and nonoxidative glucose metabolism was determined by the insulin-glucose clamp technique in conjunction with indirect calorimetry. Nonoxidative glucose metabolism which under these conditions is a measure of muscle glycogen synthesis (1990. N. Engl. J. Med. 322:223-228), was 31 +/- 7 mumol/(kg body wt-min) in the normal subjects and 13 +/- 3 mumol/(kg body wt-min) in the NIDDM subjects (P less than 0.05). The concentration of G6P was higher (0.24 +/- 0.02 mmol/kg muscle) in the normal subjects than in the NIDDM subjects (0.17 +/- 0.02, P less than 0.01). Increasing insulin concentrations to insulin 8,500 pmol/liter in four NIDDM subjects restored the glucose uptake rate and G6P concentrations to normal levels. In conclusion, the lower concentration of G6P in the diabetic subjects despite a decreased rate of nonoxidative glucose metabolism is consistent with a defect in muscle glucose transport or phosphorylation reducing the rate of muscle glycogen synthesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-115716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-14275108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2121571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2123890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2189891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2189893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2354749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2403659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2645527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2664520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-283423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2846655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-2957389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3069399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3110217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3279804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3283552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3297883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3301899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3529983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3571496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-36398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-382871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-3959889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-4000479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-4291146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-4627390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-4852173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-5785234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-6355180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-6423666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-6757010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-6757014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-6947247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-7030826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1556176-98828
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1069-75
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1556176-Aged,
pubmed-meshheading:1556176-Biological Transport,
pubmed-meshheading:1556176-Diabetes Mellitus, Type 2,
pubmed-meshheading:1556176-Glucose,
pubmed-meshheading:1556176-Glucose-6-Phosphate,
pubmed-meshheading:1556176-Glucosephosphates,
pubmed-meshheading:1556176-Humans,
pubmed-meshheading:1556176-Insulin,
pubmed-meshheading:1556176-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1556176-Male,
pubmed-meshheading:1556176-Middle Aged,
pubmed-meshheading:1556176-Muscles,
pubmed-meshheading:1556176-Phosphorylation
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pubmed:year |
1992
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pubmed:articleTitle |
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.
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pubmed:affiliation |
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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