15561391

Source:http://linkedlifedata.com/resource/pubmed/id/15561391

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021469, umls-concept:C0034929, umls-concept:C0086418, umls-concept:C0205219, umls-concept:C0234108, umls-concept:C0442043, umls-concept:C1280500, umls-concept:C1514653, umls-concept:C2587213
pubmed:issue	3
pubmed:dateCreated	2004-11-24
pubmed:abstractText	The aim of this study was to investigate the effects of diffuse noxious inhibitory controls (DNICs) on the temporal summation of the nociceptive flexion reflex (RIII reflex) in humans. Recordings were obtained from 36 healthy adults (16 M, 20 F), and the area and temporal summation threshold (TST) of the RIII reflex were measured. The subjective intensity of the painful sensation was rated on an 11-point visual analogue scale (VAS). Neurophysiological and VAS measurements were recorded after activation of DNICs by means of the cold pressor test (CPT), which involved immersing the hand in cold water (2-4 degrees C). A slight significant lower TST was found in the females versus the males. In all the subjects, the CPT induced a significant TST increase and RIII area reduction compared with the control session. The VAS results paralleled those of the RIII reflex area and TST. During the CPT, a significant difference in the percentage TST increase emerged between females and males, being lower in the former. Similarly, we found a significantly lower percentage reduction of the RIII area in women than in men during the CPT. To summarize, activation of DNICs through the CPT significantly increased the TST of the RIII reflex in healthy subjects. This inhibitory effect was gender-specific. Whereas other findings are based on psychophysical evaluations, the results of this experimental study provide an objective neurophysiological demonstration that DNICs attenuate temporal summation in humans and confirm the presence of significant differences in pain modulation mechanisms between men and women.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7508686
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0304-3959
pubmed:author	pubmed-author:AmabileGiuseppe AmadioGA, pubmed-author:NappiGiuseppeG, pubmed-author:ParisiLeolucaL, pubmed-author:PierelliFrancescoF, pubmed-author:RossiPaoloP, pubmed-author:SandriniGiorgioG, pubmed-author:SerraoMarianoM
pubmed:issnType	Print
pubmed:volume	112
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	353-60
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15561391-Adult, pubmed-meshheading:15561391-Analysis of Variance, pubmed-meshheading:15561391-Conditioning (Psychology), pubmed-meshheading:15561391-Dose-Response Relationship, Radiation, pubmed-meshheading:15561391-Electric Stimulation, pubmed-meshheading:15561391-Female, pubmed-meshheading:15561391-Humans, pubmed-meshheading:15561391-Male, pubmed-meshheading:15561391-Neural Inhibition, pubmed-meshheading:15561391-Neuropsychological Tests, pubmed-meshheading:15561391-Nociceptors, pubmed-meshheading:15561391-Pain, pubmed-meshheading:15561391-Pain Measurement, pubmed-meshheading:15561391-Pain Threshold, pubmed-meshheading:15561391-Physical Stimulation, pubmed-meshheading:15561391-Psychophysics, pubmed-meshheading:15561391-Random Allocation, pubmed-meshheading:15561391-Reflex
pubmed:year	2004
pubmed:articleTitle	Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans.
pubmed:affiliation	Department of Neurology and Otolaryngology, University of Rome La Sapienza, Italy.
pubmed:publicationType	Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial