Linked Life Data

15560980

Source:http://linkedlifedata.com/resource/pubmed/id/15560980

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-11-24
pubmed:abstractText
Compared to 'live' vaccines, the immunogenicity of 'split' vaccines based on recombinant antigen (Ag) is poor, presumably because exogeneous recombinant Ag fails to efficiently access the major histocompatibility complex (MHC) class I processing pathway needed for 'cross-presentation'. Here we discuss recent evidence that targeting ligands of the Toll-like receptor 9 together with proteinaceous Ag to the endosome of dendritic cells conveys immunogenicity to Ag similar in magnitude to 'live' vaccines that produce Ag. Enforced endocytosis of Ag together with the adjuvant effect of Toll-like receptor 9 ligands might be key for the efficient cross-presentation of exogeneous Ag as well as for effective cross-priming of MHC class I restricted CD8 T effector cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0958-1669
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
538-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Targeting split vaccines to the endosome improves vaccination.
pubmed:affiliation
Institute of Medical Microbiology, Immunology and Hygiene, Trogerstrasse. 9, 81675 Munich, Germany. h.wagner@lrz.tu-muenchen.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't